Novel and efficient synthesis of tert-butyl-2-(4-(2-aminoethyl)phenylthio)- 2-methylpropanoate, a key intermediate in the synthesis of ureido thioisobutyric acid
A convenient and cost-effective synthesis of pharmacologically important tert-butyl-2-(4-2-aminoethyl)phenylthio)-2-methylpropanoate from commercially available 2-2-phenyl-1-ethanol is described.
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]
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Brown, Peter J.,Winegar, Deborah A.,Plunket, Kelli D.,Moore, Linda B.,Lewis, Michael C.,Wilson, Joan G.,Sundseth, Scott S.,Koble, Cecilia S.,Wu, Zhengdong,Chapman, James M.,Lehmann, Jürgen M.,Kliewer, Steven A.,Willson, Timothy M.
p. 3785 - 3788
(2007/10/03)
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