- TREATING LONG QT SYNDROME
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This document relates to compounds useful for treating and preventing disorders associated with long QT syndrome such as cardiac arrhythmia, ventricular arrhythmia, hypertrophic cardiomyopathy, and congestive heart failure. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.
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Page/Page column 33
(2020/08/22)
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- A convenient copper-catalyzed direct animation of nitroarenes with 9-alkylhydroxylamines
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O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields, ortho- or para-Animation with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c-f, 14 and 22g.
- Seko, Shinzo,Miyake, Kunihito,Kavvamura, Norio
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p. 1437 - 1444
(2007/10/03)
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- Direct Nitration of Anilines Using Nitrocyclohexadienones
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Nitrocyclohexadienones (in particular, 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone) are used as reagents for the direct nitration of anilines.Depending on the conditions, good yields of C-nitroanilines are obtained.Under the same conditions, N,N-dimethylaniline is converted into N-methyl-N-nitroaniline.
- Lemaire, M.,Guy, A.,Boutin, P.,Guette, J. P.
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p. 761 - 763
(2007/10/02)
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- Quinoxaline derivatives as immune regulants
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Novel quinoxaline derivatives, useful as immune regulatory agents capable of altering the immune response in mammals.
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