- Eco-friendly microwave-assisted protocol to prepare hyaluronan-fatty acid conjugates and to induce their self-assembly process
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An environmentally sustainable and energy-efficient synthetic process has been developed to prepare hyaluronan-based nano-sized material. It consists in a microwave-promoted acylation of the hydroxyl function of the polysaccharide with natural fatty acids, performed under solvent-free conditions. The efficient interaction of the solid reagents with the MW radiation accounts for the obtained high yielded products. The self-assembly process of the obtained compounds very fast occurred in an aqueous medium under MW-radiation, thus allowing the development of a green protocol for the nano-particles preparation.
- Calce, Enrica,Mercurio, Flavia Anna,Leone, Marilisa,Saviano, Michele,De Luca, Stefania
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- NOVEL CATIONIC LIPID EXHIBITING IMPROVED INTRACELLULAR DYNAMICS
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The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R1a, R1b, R2a, R2b, R3a, R3b, Xa, Xb, Ya, Yb, Za, and Zb are as defined in the specification.
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Paragraph 0221-0223
(2021/01/29)
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- Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: An in vitro study
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Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propof
- Khan, Azmat Ali,Alam, Mahboob,Tufail, Saba,Mustafa, Jamal,Owais, Mohammad
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experimental part
p. 4878 - 4886
(2011/11/29)
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