- PRODUCTION METHOD OF ALKYL N-ACETYLGLUCOSAMINIDE
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PROBLEM TO BE SOLVED: To provide a method for obtaining alkyl N-acetylglucosaminide that comprises few content of N-acetyl glucosamine as impurities, conveniently and efficiently with a low cost. SOLUTION: The invention provides a production method of alkyl N-acetylglucosaminide comprising a step of reducing the content of N-acetyl glucosamine by contacting a mixture of alkyl N-acetylglucosaminide and N-acetyl glucosamine with strongly basic anion exchange resin (where, alkyl means an alkyl group of carbon number 1-4). The invention relates to the production method of alkyl N-acetylglucosaminide which is a mixture of alkyl N-acetylglucosaminide and N-acetyl glucosamine obtained by reaction of N-acetyl glucosamine, chitin, or chitin oligosaccharide with alkyl alcohol under the presence of an acid, or transglycosidation of chitin or chitin oligosaccharide using an enzyme with N-acetylhexosaminidase activity in a mixed solution of alkyl alcohol and water. COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0041
(2016/12/01)
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- Chemo-enzymatic approach to access diastereopure α-substituted GlcNAc derivatives
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The formation of diastereopure α-substituted GlcNAc derivatives in a simple and straightforward way is a challenging task. Herein, we report the chemical synthesis of diastereomeric α/β-substituted GlcNAc derivatives under non-anhydrous atmosphere using u
- Wang, Su-Yan,Laborda, Pedro,Lu, Ai-Min,Wang, Meng,Duan, Xu-Chu,Liu, Li,Voglmeir, Josef
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p. 423 - 434
(2017/08/23)
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- HELICOBACTER PYLORI BACTERIUM PROLIFERATION INHIBITOR
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The present invention herein provides a proliferation inhibitor of H. pylori bacteria comprising a compound that can specifically inhibit the proliferation of H. pylori bacteria, which does not generate bacterium resistant, can be eaten, drunken or administrated safely for a long period of time, can be simply mass-manufactured and can be used for foods and beverages or pharmaceutical preparation. The proliferation inhibitor of H. pylori bacteria comprises an N-acetylglucosaminyl beta-linked monosaccharide derivative represented by the following chemical formula (1): ????????GlcNAc1-beta-O-Y?????(1) wherein Y is an alkyl group, an alkoxyl group, an alkenyl group, an alkynyl group, an aralkyl group, an aryl group, a heteroaryl group, a carboxyl group or an alkoxycarbonyl group.
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Page/Page column 5
(2011/08/04)
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- Discovery of the chemical function of glycosidases: Design, synthesis, and evaluation of mass-differentiated carbohydrate libraries
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Equation presented. Discovery of the catalytic chemical function of the many putative glycosidases coded in genomes currently relies on individual testing of possible substrates, usually as their p-nitrophenol conjugate. Herein, we present an alternative chemical proteomics approach using a synthetic mass-differentiated heat-stable substrate library with mass spectrometry readout. Library components do not serve as reaction inhibitors and both primary and secondary enzyme substrates can be delineated.
- Yu, Yang,Ko, Kwang-Seuk,Zea, Corbin J.,Pohl, Nicola L.
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p. 2031 - 2033
(2007/10/03)
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