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CAS

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250264-28-9

5-chloro-1,8-naphthyridin-2(1H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 250264-28-9 Structure

  • Basic information

    1. Product Name: 5-chloro-1,8-naphthyridin-2(1H)-one
    2. Synonyms: 5-chloro-1,8-naphthyridin-2(1H)-one
    3. CAS NO:250264-28-9
    4. Molecular Formula: C8H5ClN2O
    5. Molecular Weight: 180.59
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 250264-28-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-chloro-1,8-naphthyridin-2(1H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-chloro-1,8-naphthyridin-2(1H)-one(250264-28-9)
    11. EPA Substance Registry System: 5-chloro-1,8-naphthyridin-2(1H)-one(250264-28-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 250264-28-9(Hazardous Substances Data)

250264-28-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 250264-28-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,0,2,6 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 250264-28:
(8*2)+(7*5)+(6*0)+(5*2)+(4*6)+(3*4)+(2*2)+(1*8)=109
109 % 10 = 9
So 250264-28-9 is a valid CAS Registry Number.

250264-28-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Chloro-1,8-naphthyridin-2(1H)-one

1.2 Other means of identification

Product number -
Other names 2-hydroxy-5-carboxymethylmuconate semialdehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:250264-28-9 SDS

250264-28-9Relevant articles and documents

Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents - Part VIII

Ferrarini, Pier Luigi,Mori, Claudio,Calderone, Vincenzo,Calzolari, Lorella,Nieri, Paola,Saccomanni, Giuseppe,Martinotti, Enrica

, p. 505 - 513 (1999)

A series of (ethoxycarbonylpiperazinyl)- and piperazinyl- 1,8- naphthyridine derivatives, variously substituted, has been synthesized and pharmacologically investigated for anthihypertensive activity. Some of them exhibited a significant and prolonged decrease of the mean arterial pressure (MAP) on spontaneously hypertensive rats. On the basis of the pharmacological results, no structure-activity relationship can be deduced at this time. Moreover, the most active compound 4e, was investigated by means of in vitro pharmacological functional studies and in vivo, as a diuretic agent, to determine a possible mechanism of the antihypertensive activity, which results in a probably non-competitive antagonism against α1 vascular adrenoceptors. This mechanism was also shown by the compounds 8 and 13.

NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS

-

Page/Page column 57-58, (2010/04/03)

Naphthyridinone derivative compounds that inhibit Aurora kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative di

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