- Preparation of chiral right-half models of antitumor bistetrahydroisoquinolinequinone natural products
-
– The preparation of chiral right-half model compounds of bistetrahydroisoquinolinequinone natural products having a lactam carbonyl group (-)-1 or an aminonitrile group (+)-2 from (-)-14 was presented. The crucial steps of this synthesis include the N-methylation of compound (-)-12 and ring closure to generate (-)-19a without any epimerization at C-2.1
- Senbonmatsu, Yuki,Kimura, Shinya,Akiba, Megumi,Ando, Shingo,Saito, Naoki
-
p. 1050 - 1067
(2019/07/31)
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- The method of preparation of enantiomerically enriched products of condensation from racemic acids or acids of the low enentiomeric purity
-
The method of obtaining enantiomerically enriched condensation products consists of subjecting a racemic acid or an acid of low enantiomeric purity to the action of a condensing reagent - a chiral N-triazinylammonium tetrafluoroborate (formula 1), a chira
- -
-
Page/Page column 6
(2012/03/08)
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- Phosphine-based redox catalysis in the direct traceless staudinger ligation of carboxylic acids and azides
-
Redox catalysis: Aryl amides, imides, lactams, and dipeptides are obtained through a direct Staudinger ligation mediated by phosphine-based redox catalysis (see scheme). Mechanistic studies indicate the involvement of a phosphonium carboxylate intermediate that leads to a 1,3-acyl migration and thus results in C-N bond formation. Copyright
- Kosal, Andrew D.,Wilson, Erin E.,Ashfeld, Brandon L.
-
supporting information
p. 12036 - 12040
(2013/01/16)
-
- Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters
-
Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild condi
- Chen, Hao,He, Maomao,Wang, Yaya,Zhai, Linhui,Cui, Yongbo,Li, Yangyan,Lee, Yan,Zhou, Haibing,Hong, Xuechuan,Deng, Zixin
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supporting information; experimental part
p. 2723 - 2726
(2011/11/06)
-
- A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
-
A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of t
- Baxendale, Ian R.,Ley, Steven V.,Smith, Christopher D.,Tranmer, Geoffrey K.
-
p. 4835 - 4837
(2007/10/03)
-
- A new method for the synthesis of carboxamides and peptides using 1,1′-carbonyldioxydi[2(1H)-pyridone] (CDOP) in the absence of basic promoters
-
Various carboxamides or peptides are synthesized from the corresponding carboxylic acids and amines or α-amino acids using 1,1′-carbonyldioxydi[2(1H)-pyridone]. The reaction proceeds in the absence of basic promoters such as triethylamine or 4-(dimethylamino)pyridine, therefore, the undesired racemization does not occur at all in the segment coupling producing Z-Gly-Phe-Val-OMe and Z-Phe-Val-Ala-OMe.
- Shiina, Isamu,Kawakita, Yo-Ichi
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p. 1951 - 1955
(2007/10/03)
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- N, N′-Carbonyldisaccharin: A new condensing agent for the synthesis of amides, esters and peptides
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A new, easy to handle and efficient condensing agent N,-N′ -carbonyldisaccharin 2 has been readily synthesised by the reaction of saccharin 1 and trichloromethyl chloroformate in toluene. The condensing agent 2 is demonstrated to be useful for the synthesis of amides, esters and dipeptides under mild conditions in a one-pot procedure.
- Yadav,Dubey, Suman,Singh, Amrish
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p. 2601 - 2603
(2007/10/03)
-
- A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines
-
Coupling of racemic N-protected amino acids with amino components by means of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) in the presence of chiral tertiary amines such as strychnine, brucine, and sparteine proceeds enantioselectively, affording appropriate amides or dipeptides in 69-85% yield. The configuration of the preferred enantiomer and enantiomeric enrichment depend on the structures of the amine and carboxylic acid. Calculated Kagan enantioselectivity parameters (s) are in the range 1.6-195. Chiral triazinylammonium chlorides formed in situ from CDMT and chiral tertiary amines are postulated as reactive intermediates involved in the process of enantioselective activation of N-protected amino acids.
- Kaminski,Kolesinska,Kaminska,Gora
-
p. 6276 - 6281
(2007/10/03)
-
- New system for peptide synthesis using N-acylpyrazoles
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New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.
- Kashima, Choji,Tsuruoka, Shiro,Mizuhara, Saori
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p. 413 - 424
(2007/10/03)
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- A New Route toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine
-
Treatment of sodium N-(o-azidobenzoyl)aminoacylglycinates 8 with acetic anhydride afforded 1-acetyl-4-(o-azidobenzoyl)-2,5-piperazinediones 7, with complete retention of the stereochemistry. The intramolecular aza Wittig reactions of compounds 7 in the pr
- Cledera, Pilar,Avendano, Carmen,Carlos Menendez
-
p. 1743 - 1749
(2007/10/03)
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- A convenient method for the preparations of carboxamides and peptides by using di(2-pyridyl) carbonate and O,O′-di(2-pyridyl) thiocarbonate as dehydrating reagents
-
Preparations of carboxamides and peptides are performed in high yields from free carboxylic acids and amines by dehydration condensation using di(2-Pyridyl) carbonate (DPC) or O,O′-Di(2-Pyridyl) thiocarbonate (DPTC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP). The formation of 2-Pyridyl esters, key intermediates of the reaction, from carboxylic acids by using DPC proceeded faster than by using DPTC; therefore, the former carbonate is more efficiently employed in the above condensation reactions.
- Shiina,Suenaga,Nakano,Mukaiyama
-
p. 2811 - 2818
(2007/10/03)
-
- Oxidation-induced Acyl group transfer from hydroquinone esters to nucleophiles
-
Bivalent oxidation of 3,5-di-tert-butyl-hydroquinone monoesters leads to phenoxenium ions, which can transfer an acyl group to nucleophiles. Based on this principle, dipeptides, glyco-amino acids and N-sulfonyl-amino acids were synthesized from hydroquino
- Reischl, Gerald,El-Mobayed, Medhat,Bei?wenger, Rudolf,Regier, Klaus,Maichle-M?ssmer, C?cilia,Rieker, Anton
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p. 765 - 773
(2007/10/03)
-
- A novel organophosphorus compound as a coupling reagent for peptide synthesis
-
3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4 (3H)-one 1 is a new organophosphorus compound which can be used as an efficient coupling reagent for peptide synthesis by either solution or solid phase coupling.
- Fan, Chong-Xu,Hao, Xiao-Lin,Ye, Yun-Hua
-
p. 1455 - 1460
(2007/10/03)
-
- New Carbodiimides for Peptide Synthesis
-
Three carbodiimides: N,N'-dicyclopentylcarbodiimide, N,N'-di-2-methylcyclohexylcarbodiimide and N,N'-dimenthylcarbodiimide were prepared and used for activation of the carboxyl group in peptide coupling reactions.Several model reactions were carried out t
- Orlowska, A.,Izdebski, J.
-
p. 713 - 718
(2007/10/02)
-
- Synthesis of a new saccharin derivative (BID-SPy) and its utilization as a condensing reagent in the preparation of dipeptides
-
A new saccharin derivative, thiopyridyl-benzisothiazole 1,1-dioxide (BID-SPy, 2), has been prepared by the reaction of BID-Cl (1) and 2-mercaptopyridine, and utilized as a coupling reagent in the synthesis of amides and N-protected dipeptides.
- Ahmed, A,Akhter, H
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p. 564 - 565
(2007/10/02)
-
- SYNTHESES VIA ANODICALLY PRODUCED PHENOXENIUM IONS. APPLICATIONS IN THE FIELD OF PEPTIDES AND CARBOHYDRATES
-
Sterically hindered phenols are anodically oxidized to the corresponding phenoxenium ions which react with O- and N-nucleophiles to give cyclohexadienyl-protected nucleophiles. 4-Acyloxy substituted phenoxenium ions can transfer the acyl group to nucleoph
- Rieker, Anton,Beisswenger, Rudolf,Regier, Klaus
-
p. 645 - 654
(2007/10/02)
-
- An improved method for the synthesis of active esters of N-protected amino acids and subsequent synthesis of dipeptides
-
4-Dimethylaminopyridine-catalyzed reaction of mixed carbonates 3 with N-protected amino acids 4 gave the corresponding active esters 5-9, from which dipeptides 11-18 were synthesized by aminolysis with amino acids 10.
- Takeda,Ayabe,Suzuki,Konda,Harigaya
-
p. 689 - 691
(2007/10/02)
-
- Enol esters as intermediates for the facile conversion of amino acids into amides and dipeptides
-
N-Protected amino enol esters are easily transformed at room temperature into amino amides, and in the presence of potassium cyanide as catalyst, into tertiary amides and dipeptides.
- Kabouche,Bruneau,Dixneuf
-
p. 5359 - 5362
(2007/10/02)
-
- Amino acid fluorides: Their preparation and use in peptide synthesis
-
Z or Fmoc amino acid fluorides have been prepared from the protected amino acids and cyanuric fluoride, and have been tested both in the condensation with simple amino acid esters and in Solid Phase Peptide Synthesis.
- Bertho, Jean-Noeel,Loffet, Albert,Pinel, Catherine,Reuther, Florence,Sennyey, Gerard
-
p. 1303 - 1306
(2007/10/02)
-
- Synthesis and Characterisation of some New Diazopeptides
-
The synthesis of eight new diazopeptides by aprotic diazotisation with N2O4 is described for glycylglycine, triglycine, pentaglycine, L-leucylglycine and the ethyl esters of L-leucylglycine, L-alanylglycine, L-serylglycine and L-threonylglycine.The diazo derivatives (7) - (10) of the parent peptides are isolated as calcium salts.The UV-vis., IR, 1H NMR and MS properties of the new diazopeptides are reported together with those for the diazo derivative of glycylglycine ethyl ester and glycylglycinamide.
- Challis, Brian C.,Latif, Farida
-
p. 1005 - 1009
(2007/10/02)
-
- KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS
-
The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.
- Hoogwater, D. A.,Peereboom, M.
-
p. 5325 - 5332
(2007/10/02)
-
- Novel reactions of S,S'-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate
-
S,S'-Bis(1-phenyl-1H-5-yl) dithiocarbonate (1) was synthesized in good yield from 1-phenyl-5-mercapto-5H-tetrazole (2) and trichloromethyl chloroformate (TCF).The structure of 1 was confirmed by using X-ray crystal analysis.The reagent (1) could be applied to the formation of amides, Friedel-Crafts type reactions, isothiocyanate syntheses, and carbonyl group insertion reactions.Keywords - S,S'-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate; X-ray crystal analysis; amide; isothiocyanate; Friedel-Crafts reaction; carbonyl group insertion reaction.
- Takeda, Kazuyoshi,Tsuboyama, Kanoko,Takayanagi, Hiroaki,Shirokami, Rie,Takeura, Masumi,Ogura, Haruo
-
p. 2334 - 2337
(2007/10/02)
-
- Facile Conversions of Carboxylic Acids into Amides, Esters, and Thioesters Using 1,1'-Oxalyldiimidazole and 1,1'-Oxalyldi(1,2,4-triazole)
-
Aliphatic, aromatic, and heteroaromatic carboxylic acids react with 1,1'-oxalyldiimidazole (1) or 1,1'-oxalyldi(1,2,4-triazole) (2) in acetonitrile for 40 min at 40 degC to give the corresponding 1-acylazole intermediates (11), which promptly undergo aminolysis and alcoholysis to form amides (13) including dipeptides (14), esters (16), and thioesters (19).These findings show that both 1 and 2 can be utilized as condensing reagents for the synthesis of carboxylic acid derivatives.Keywords --- 1,1'-oxalyldiimidazole; 1,1'-oxalyldi(1,2,4-triazole); 1,1'-carbonyldiimidazole; 1-acylazole; condensing reagent; amidation; esterification; dipeptide; aminolysis; alcoholysis
- Kitagawa, Tokujiro,Kuroda, Hiroko,Sasaki, Hideaki,Kawasaki, Koichi
-
p. 4294 - 4301
(2007/10/02)
-
- THE CINNAMYLOXYCARBONYL GROUP AS A NEW AMINO-PROTECTING GROUP
-
A new urethane-type protecting group for amines, cinnamyloxycarbonyl (Coc) group, is described.The cleavage of the Coc group is effectively catalyzed by 5 molpercent of in the presence of formic acid, pyridine, and N-hydroxysuccinimide in ref
- Kinoshita, Hideki,Inomata, Katsuhiko,Kameda, Takuo,Kotake, Hiroshi
-
p. 515 - 518
(2007/10/02)
-
- A SIMPLE METHOD FOR SYNTHESIS OF AMIDES AND PEPTIDES THROUGH ACYL CHLORIDES. A RAPID SYNTHESIS OF THYROTROPIN RELEASING HORMONE
-
By improvement of the classical SOCl2-pyridine method for the preparation of acid chlorides, amides and optically pure peptides were synthesized rapidly in a simple manner from DCHA (dicyclohexylammonium) salts of carboxylic acids.This modified SOCl2-pyridine method was applied to a rapid synthesis of TRH.
- Matsuda, Fuyuhiko,Itoh, Shin,Hattori, Noritaka,Yanagiya, Mitsutoshi,Matsumoto, Takeshi
-
p. 3625 - 3631
(2007/10/02)
-
- 3,3'-(Phenylphosphinylidene)bis and 3,3'-(Phenylphosphinylidene)bis. New Activating Agents
-
New activating agents, 3,3'-(phenylphophinylidene)bis (4) and 3,3'-(phenylphosphinylidene)bis (5), were readily prepared by the reaction of phenylphosphonic dichloride (3) with 2(3H)-benzoxazolone (1) and 2(3H)-benzothiazolone (2) respectively in the presence of triethylamine at room temperature.The new activating agents 4 and 5 were found to be useful for the preparation of amides, esters, and dipeptides under mild conditions.Furthemore, the direct polycondensation of isophthalic acid with aromatic diamines using the activating agent 4 in the presence of pyridine proceeded fast at room temperature to produce polyamides with inherent viscosities up to 0.80 dL/g.
- Ueda, Mitsuru,Mochizuki, Amane,Hiratsuka, Ichiro,Oikawa, Hideaki
-
p. 3291 - 3297
(2007/10/02)
-
- 1,2-Benzisoxazol-3-yl Diphenyl Phosphate: A New, Reactive Activating Agent for the Synthesis of Amides, Esters, and Peptides via Condensation
-
A new activating agent for condensations, 1,2-benzisoxazol-3-yl diphenyl phosphate (1), was readily prepared in high yield by the reaction of 1,2-benzisoxazol-3-ol (2) with diphenyl phosphorochloridate (3) in the presence of triethylamine in benzene.The reaction of the carboxylic acids with the amines in the presence of 1 was investigated by two procedures, a two-step method and a one-step procedure.Both methods gave the corresponding amides and esters in high yields under mild conditions, but the one-step procedure was found to be superior to the two-step procedure because of its simplicity and speed.Furthermore, the activating agent 1 was shown to be a useful peptide forming reagent.
- Ueda, Mitsuru,Oikawa, Hideaki
-
p. 760 - 763
(2007/10/02)
-
- THE SYNTHESIS OF AMIDES, ESTERS, AND THIOESTERS
-
Diethyl 2-(3-oxo-2,3-dihydro-1,2-benzisosulfonazolyl)phosphonate is a highly reactive condensing agent, which provides good yield route to amides, esters, and thioesters from a variety of amines, active hydroxylamines, and thiols and acids.
- Miyake, Muneharu,Kirisawa, Makoto,Tokutake, Norio
-
p. 123 - 126
(2007/10/02)
-
- Peptide-bond Formation, Chemoselective Acylation of Amino Acids, and Crosslinking Reaction between Amino Acids Utilizing a Functional Five-membered Heterocycle, 1,3-Thiazolidine-2-thione
-
The monitored aminolysis of 3-acyl-1,3-thiazolidine-2-thiones has been extended to the peptide-bond formation, the chemoselective acylation of amino acids having multifunctional groups, and the crosslinking reaction between amino acids.
- Nagao, Yoshimitsu,Miyasaka, Tadayo,Seno, Kaoru,Fujita, Eiichi,Shibata, Daisuke,Doi, Etsushiro
-
p. 2439 - 2446
(2007/10/02)
-
- Design and Synthesis of Enkephalin Analogues: Part II - Synthesis of 2, Met5>-Enkephalin Alkylamides Having Morphinomimetic Activity
-
Alkylamides of 2, Met5>-enkephalin have been synthesized by two different routes.The first method consists of the sequential peptidation of Phe-Met-ONBzl by 2,4,5-trichlorophenyl esters of Boc-Gly, Boc-D-Ala and Boc-Tyr to get
- Dhotre, B. J.,Mathur, K. B.
-
p. 1231 - 1236
(2007/10/02)
-
- KINETICS OF AMINOLYSIS FOR 1-THIO-β-D-GLUCOPYRANOSYL ESTERS OF N-ACYLALANINES
-
The kinetics of aminolysis of 1-thio-β-D-glucopyranosyl esters of N-protected alanines (1) in dichloromethane at 26 deg C, by ethyl glycinate, under pseudo-first-order conditions follows the relationship kobsd=k2.Significant differences were obserwed in the rates of dipeptide forming aminolysis for 1-thiolesters 1a-1f, depending on N-acyl substituents and the configuration of alanine.
- Horvat, S.,Tomic, S.,Jericevic, Z.
-
p. 1047 - 1050
(2007/10/02)
-
- Reactivity of Aromatic o-Hydroxy Oximes. II. The Use of Esters of Aromatic o-Hydroxy Oximes in Peptide Synthesis
-
Esters of N-protected amino acids with o-hydroxybenzaldehyde oxime, o-hydroxyacetophenone oxime, o-hydroxybenzophenone oxime, and their 5-Cl and 5-NO2 derivatives were prepared by several methods.Various dipeptide derivatives with high purity were obtaine
- Hayashi, Ikuo,Shimizu, Kiyoshi
-
p. 3197 - 3198
(2007/10/02)
-
- ACTIVATION OF CARBOXYL GROUPS BY DIPHENYL 2-OXO-3-OXAZOLINYLPHOSPHONATE. FACILE PREPARATION OF VERSATILE REAGENTS, 3-ACYL-2-OXAZOLONES
-
Synthetic utility of the 2-oxazolone moiety as an excellent new leaving group is described.Based on such a function of the heterocycles, diphenyl 2-oxo-3-oxazolinylphosphonate has been newly introduced as a carboxyl-activating reagent which permits a facile direct preparation of 3-acyl-2-oxazolones and amides including peptides from a wide variety of carboxylic acids.The 3-acyl-2-oxazolides also serve as versatile reactive agents for highly chemoselective acyl-transfer to the nucleophilic species such as amines, alcohols and thiols, providing convenient and high-yield routes to amides, esters and thiol esters under mild conditions.They are also useful intermediates for ketones and alcohols.
- Kunieda, Takehisa,Higuchi, Tsunehiko,Abe, Yoshihiro,Hirobe, Masaaki
-
p. 3253 - 3260
(2007/10/02)
-
- A Convenient Synthesis of Peptide Using Oxallates
-
The equimolar reactions of N-protected amino acids , amino acids or amino acid esters with oxallates (1a-1e) having active ester groups in the presence of pyridine in acetonitrile afforded the corresponding dipeptides via active esters in good yields.
- Takeda, Kazuyoshi,Sawada, Izumi,Suzuki, Akira,Ogura, Haruo
-
p. 4451 - 4454
(2007/10/02)
-
- 1,2-BENZISOXAZOL-3(2H)-ONE.
-
A new condensing agent, N,N prime -carbonyldi left bracket 1,2-benzisoxazol-3(2H)-one right bracket (6), was readily prepared by the reaction of 1,2-benzisoxazol-3-ol and trichloromethyl chloroformate in toluene. The condensing agent 6 was shown to be very useful for the preparation of amides, esters, and dipeptides under mild conditions. A successful polyamide synthesis by one-pot polycondensation of isophthalic acid with diamines using 6 is also described.
- Ueda,Oikawa,Kawaharasaki,Imai
-
p. 2485 - 2489
(2007/10/02)
-
- MONITORED AMINOLYSIS OF 3-ACYL-1,3-THIAZOLIDINE-2-THIONE WITH AMINO ACID AND ITS DERIVATIVE: PEPTIDE BOND FORMATION, CHEMOSELECTIVE ACYLATION, AND BRIDGING REACTION
-
As a new extention of the monitored aminolysis of 3-acyl-1,3-thiazolidine-2-thione, its applications to peptide bond formation, chemoselective acylation of amino acid, and bridging reaction on the enzyme model are reported.
- Nagao, Yoshimitsu,Miyasaka, Tadayo,Seno, Kaoru,Yagi, Masahiro,Fujita, Eiichi
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p. 463 - 466
(2007/10/02)
-
- A NEW REAGENT FOR ACTIVATING CARBOXYL GROUPS: DIPHENYL 2-OXO-3-OXAZOLINYLPHOSPHONATE
-
Diphenyl 2-oxo-3-oxazolinylphosphonate serves as a carboxyl-activating reagent to permit a direct preparation of versatile intermediate, 3-acyl-2-oxazolones or a one-step formation of amides from carboxylic acids.
- Kunieda, Takehisa,Abe, Yoshihiro,Higuchi, Tsunehiko,Hirobe, Masaaki
-
p. 1257 - 1258
(2007/10/02)
-
- 3-O--HYDROXY-2-PHENYLINDENONES, PREPARATION AND USE IN THE SYNTHESIS OF PEPTIDES
-
Several 3-O--hydroxy-2-phenylindenones were obtained and used in the synthesis of peptides.Synthesis of Leu-enkephalin was carried out.
- Mincev, Stoyan,Derdowska, Izabela,Kupryszewski, Gotfryd
-
p. 443 - 452
(2007/10/02)
-
- FORMATION OF N-ACYL DERIVATIVES OF N,N'-DISUBSTITUTED UREA IN THE REACTION OF PEPTIDE BOND FORMATION BY THE CARBODIIMIDE METHOD. PART V. USE OF N,N'-DIISOPROPYLCARBODIIMIDE IN PEPTIDE SYNTHESIS.
-
Reactions of peptide bond formation were carried out using N,N'-diisopropylcarbodiimide (DIC) as a coupling reagent.The participation of the reaction of rearrangement to the N-acyl derivative of N,N'-diisopropyl urea in all the conversions of the acylatin
- Izdebski, Jan,Kunce, Danuta,Drabarek, Stefania
-
p. 413 - 418
(2007/10/02)
-
- 3-(5-NITRO-2-PYRIDON-1-YL)-1,2-BENZOISOTHIAZOLE 1,1-DIOXIDE (BID-NPy) AS A NEW EFFECTIVE CONDENSING REAGENT
-
3-(5-Nitro-2-pyridon-1-yl)-1,2-benzoisothiazole 1,1-dioxide (BID-NPy) was found to be a useful condensing reagent.Various dipeptides and esters were prepared in good yields using this reagent.
- Ahmed, Alauddin,Fukuda, Hirohiko,Inomata, Katsuhiko,Kotake, Hiroshi
-
p. 1161 - 1164
(2007/10/02)
-