- Benzothiazole disperse dye monomer compound, synthesis method and application thereof
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The invention discloses a benzothiazole disperse dye monomer compound. The structure of the compound is shown as formula (I) in the specification, wherein X1 and X4 are hydrogen, halogen, nitro, methyl or methoxy independently; X2 and X3 are independently hydrogen, halogen, nitro, methyl, methoxy or cyano; X5 is hydrogen or C1-C4 alkoxy; X6 is hydrogen, C1-C4 alkyl, NHCOR1 or halogen, and R1 is C1-C4 alkyl. The invention also discloses a preparation method of the benzothiazole disperse dye monomer compound and application thereof in preparation of disperse dyes. According to the invention, a phenylthiourea compound is adopted as the starting raw material, and by means of condensation ring closure, diazotization and coupling, a disperse dye filter cake can be obtained. The obtained dispersedye has bright color, high coloring intensity, good dyeing reproducibility, and has excellent promotion performance, dye uptake, dyeing fastness, sunlight resistance and sublimation fastness.
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Paragraph 0076-0082
(2019/10/02)
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- IMIDAZO[2,1-B]THIAZOLE AND 5,6-DIHYDROIMIDAZO[2,1-B]THIAZOLE DERIVATIVES USEFUL AS S100-INHIBITORS
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A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is useful for use in the treatment of cancer, an inflammatory disorder,an autoimmunity disorder or a neurodegenerative disorder.
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- Synthesis and antibacterial activity of a novel series of 2,3-diaryl-substituted-imidazo(2,1-b)-benzothiazole derivatives
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Benzothiazole and imidazole compounds are extensively studied heterocyclics due to their wide spectrum of bioactivities. Among them, the imidazo(2,1-b)-benzothiazole derivatives are pharmacologically important because of their immunostimulant, anti-inflammatory, antifungal, antimicrobial, antitumor, and other activities. In the present research work, a novel series of 2,3-diaryl-substituted imidazo(2,1-b)-benzothiazoles 13a-o have been synthesized by reaction of substituted 2-aminobenzothiazoles 1-8 and an appropriately substituted a-bromo-1-(4″-substituted)-phenyl-2-(4′- substituted)-phenyl-1-ethanones 9-12 in the presence of anhydrous acetonitrile. They were characterized by physicochemical, elemental, and spectral (IR, 1H-NMR, and Mass) data. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-positive, Gram-negative bacteria. The investigation of antibacterial screening data revealed that most of the compounds tested have demonstrated congruent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard ampicillin. Among the series, compounds 13d, 13h, and 13m exhibited excellent an antibacterial activity profile as compared with the standard. In summary, preliminary results indicate that some of the newly synthesized title compounds exhibited promising antibacterial activities and they warrant more consideration as prospective antimicrobials.
- Palkar, Mahesh,Noolvi, Malleshappa,Sankangoud, Ramappa,Maddi, Veeresh,Gadad, Andanappa,Nargund, Laxmi Venkat G.
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experimental part
p. 353 - 359
(2011/07/08)
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- Synthesis of some 5-nitro-2-furfurylidene derivatives and their antibacterial and antifungal activities
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A number of new 5-nitro-2-furfurylidene derivatives 9a-k were synthesized by the reaction of 2-methyl-4-(5-nitro-2-furfurylmethyliden)-Δ2-oxazolin-5-one 6 or 2-phenyl-4-(2-furfurylmethyliden)-Δ2-oxazolin-5-one 7 with appropriate 2-aminobenzothiazole. The compounds synthesized were identified by 1H-NMR, IR, MS and micro analysis. All compounds studied in this work were screened for their in vitro antimicrobial and antifungal activities against the standard strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, and the yeast Candida albicans.
- Charris, Jaime,Monasterios, Melina,Dominguez, Josee,Infante, Wilson,Castro, Norma De
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p. 275 - 280
(2007/10/03)
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