Increased Affinity of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotides to RNA through Conjugation of Spermine at Cytidines
Structural modification at the 2′-O-position of riboses in oligonucleotide therapeutics is of critical importance for their use as drugs. To date, the methoxyethyl (MOE) substituent is the most important and features in dozens of antisense oligonucleotide
Decuypere, Elodie,Lepikhina, Anastasia,Halloy, Fran?ois,Hall, Jonathan
NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
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(2019/04/27)
2'-O-MOE-3'-H-phosphorothioate nucleoside monomer and synthetic method thereof
The invention discloses 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and 2'-O-MOE-3'-H-phosphorothioate ribonucleotide and precursor compounds thereof, preparation methods and applications of the 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and the
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Paragraph 0068; 0069
(2017/01/23)
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