- CARNITINE CONJUGATES AS DUAL PRODRUGS, METHODS OF PRODUCTION AND USES THEREOF
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The present invention discloses novel dual prodrug compounds of formula (1), methods for their preparation and intermediates in their syntheses, formula (1): wherein A is a single bond, -0-, or -CH2-; m and n vary independently and are an integer from 1 to 15; p and q vary from 0 to an integer from 1 to 4; B is a single bond or -CR3R4; D is formula (2): or formula (3): and X is halogen; R1 to R4 are various substituents selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokinetics of compounds of Formula 1; and R1 and R2 or R3 and R4 may optionally be tethered together to form a 3- to 7-membered alicyclic ring. These compounds are useful for the treatment of various infections, metabolic, cardiovascular and neurological disorders.
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Page/Page column 30-32
(2010/11/30)
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- Relationship between the Electronic Structure of Acrylic and Methacrylic Acid and the Rates of Hydrogenation of Their Salts on Pt Black
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We have studied the hydrogenation of the alkali metal salt of acrylic and methacrylic acid on platinum black.The relative reactivities, which are interest in calculations of the electronic structure of acids, have been determined by the CNDO/2 method.
- Volkova, L. D.,Vyaznikovtseva, O. V.,Gabdrakipov, V. Z.,Sokol'skii, D. V.
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p. 1650 - 1652
(2007/10/02)
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