- A Stereoselective Total Synthesis of 11-Oxoprogesterone, a Precursor to the Corticosteroids, via an Intramolecular Cycloaddition Reaction
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A stereoselective synthesis of 11-oxoprogesterone (pregn-4-ene-3,11,20-trione) (21) has been achieved via 19-norpregna-4,9(10)-diene-3,20-dione (14) and pregna-4,9(10)-diene-3,20-dione (18).The compound (14) was derived from the des-A,B-aromatic steroid (6), which was, in turn, constructed in a stereoselective manner via (3) by the thermolysis of the olefinic benzocyclobutene (2).
- Nemoto, Hideo,Nagai, Mitsuo,Fukumoto, Keiichiro,Kametani, Tetsuji
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p. 1621 - 1626
(2007/10/02)
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