- Axitinib intermediate compound and preparation method thereof
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The invention belongs to the field of pharmaceutical chemicals, and particularly relates to an axitinib intermediate compound and a preparation method thereof. The present invention provides a novel axitinib intermediate compound S-(2-(methylcarbamoyl) phenyl) dimethylthioformate, the invention also provides a preparation method thereof. The method comprises the following steps: dissolving 2-hydroxy-N-methylbenzamide in an organic solvent, and adding dimethylaminothioformyl chloride and a catalyst to obtain the S-(2-(methylcarbamoyl) phenyl) dimethylthioformate. The new intermediate compound can be used for preparing the axitinib important intermediate 2-sulfydryl-N-methylbenzamide, and the synthesis method provided by the invention is short in route, simple to operate and high in yield and purity of the obtained 2-sulfydryl-N-methylbenzamide, and is suitable for industrial production.
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Paragraph 0075; 0077
(2021/01/24)
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- Preparation method of chemical intermediate 2,2'-dithiobenzamide compound
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The invention provides a preparation method of a chemical intermediate 2,2'-dithiobenzamide compound, which comprises the following steps: reacting a 2-substituted benzamide compound with a sulfur reagent in an aprotic solvent with a high boiling point under the combined action of a metal salt and a ligand to generate a 2,2'-dithiobenzamide compound. The 2,2'-dithiobenzamide compound provided by the invention is an important chemical intermediate, the synthetic process route is simple, and the pollution of three wastes to the environment is reduced while the cost is reduced.
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Paragraph 0089-0090
(2020/07/02)
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- ALKYNYL INDAZOLE DERIVATIVE AND USE THEREOF
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The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like. The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof.
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Paragraph 0246; 0247
(2017/02/24)
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- NOVEL ULK1 INHIBITORS AND METHODS USING SAME
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In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
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Page/Page column 145
(2016/03/22)
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- Effective Laboratory-Scale Preparation of Axitinib by Two CuI-Catalyzed Coupling Reactions
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The discovery and development of an efficient synthesis route to axinitib is reported. The first-generation route researched by Pfizer implemented two Pd-catalyzed coupling reactions as key steps. In this work, the development of Heck-type and C-S coupling reactions catalyzed by CuI is briefly described, using an economial and practical protocol. Aspects of this route, such as selecting optimal ligands, solvent, and other conditions, are discussed in detail. The scale-up experiment was carried out to provide more than 300 g of active pharmaceutical ingredients of axitinib in Form XLI with 99.9% purity in 39% yield. In short, we provide a new choice of synthesis route to axitinib, through two copper-catalyzed coupling reactions with good yield.
- Zhai, Li-Hai,Guo, Li-Hong,Luo, Yang-Hui,Ling, Yang,Sun, Bai-Wang
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p. 849 - 857
(2015/07/27)
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- Crucial role of selenium in the virucidal activity of benzisoselenazol- 3(2h)-ones and related diselenides
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Various N-substituted benzisoselenazol-3(2H)-ones and their non-seleniumcontaining analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol- 3(2H)-ones-diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.
- Pietka-Ottlik, Magdalena,Potaczek, Piotr,Piasecki, Egbert,Mlochowski, Jacek
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experimental part
p. 8214 - 8228
(2011/03/19)
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- Design, syntheses, and characterization of dioxo-molybdenum(vi) complexes with thiolate ligands: Effects of intraligand NH...S hydrogen bonding
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Presence of the hydrogen bonding near a metal center can influence the properties of the complex. Here, we describe changes in redox and spectral properties in discrete dioxo-molybdenum centers coordinated by a single thiolato ligand that can support an intra-ligand hydrogen bond. We have utilized thiophenolato ligands that can harbor hydrogen bonding between the thiophenolato sulfur with an amide functionality creating either a five- or a six-membered ring. Methylation of the amide functionality removes the NH...S hydrogen bonding thus providing a basis for understanding the effect of hydrogen bonding. These thiophenolato ligands have been used in synthesizing dioxo-MoVI complexes of type Tp*MoO2(S-o-RC6H4), where R = CONHMe (11), CONMe2 (12), NHCOMe (13), and N(Me)COMe (14). The complexes have been characterized by NMR, infrared, and UV-visible spectroscopy. Spectroscopic data clearly indicate the presence of hydrogen bonding in both 11 and 13, and stronger in 13, where hydrogen bonding stabilizes a five-membered ring. All complexes exhibit a MoVI/MoV redox couple and redox potentials are modulated by the nature of H-bonding. Compound 14 with the electron-releasing N(Me)COMe group has the highest reduction potential and is more difficult to reduce. The Royal Society of Chemistry.
- Sengar, Raghvendra S.,Miller, Jonathan J.,Basu, Partha
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p. 2569 - 2577
(2008/09/20)
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- METHODS FOR PREPARING INDAZOLE COMPOUNDS
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The invention relates to methods for preparing indalzole compounds having formula (I) or pharmaceutically acceptable salts or solvates thereof. Compounds of the formula (I) are useful as anti-angiogenesis agents and as agents for modulating and/or inhibiting the activity of protein kinases, thus providing treatments for cancer or other diseases associated with cellular proliferation mediated by protein kinases.
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Page/Page column 27
(2008/06/13)
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- Structure and mechanism of hydrolysis of diaryl(acylamino)(chloro)-λ4-sulfanes and diaryl(acylamino)sulfonium salts
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Aryl (methylaminocarbonylaryl) sulfides were converted by t-BuOCl to diaryl(acylamino)(chloro)-λ4-sulfanes or the corresponding diaryl(acylamino)sulfonium chlorides depending on the substituent of the S-aryl group. 1H NMR data showed that chloro-λ4-sulfanes exist only in CDCl3 and DMSO-d6 solvents, whereas in CD3OD complete ionic dissociation takes place, leading to sulfonium chlorides. Both the chemical shifts of 1H NMR signals and NOE data suggest that chloro-λ4-sulfanes and sulfonium salts having an o-MeO, o-Cl or o-Me substituent on the phenyl ring assume a skew conformation, whereas the aryl ring in compounds without an ortho-substituent can rotate practically free about the S-C(1') axis. In o-MeO-substituted derivatives there exists an equatorial 1,4 type S...O close contact. Sulfonium salts with axial 1,5 type S...O close contacts involving neighbouring COOMe, CONHMe, COMe or NO2 groups occur in butterfly conformation, like spiro-λ4-sulfanes. There is a correlation between the 15N chemical shift of the amide-nitrogen and the elongation of the S-N covalent bond, by which the interdepending S-N, S-Cl and S...O bonds can be characterized. Effective intermolecular S...O interaction was detected between the sulfonium centre and solvent molecules having a negatively polarized oxygen atom. The hydrolysis of sulfonium salts yielding sulfoxides was investigated by a kinetic method in 98:2 (v/v) dioxane-water mixture and in water. On the basis of medium, substituent (ρ + 1.03), steric, salt and kinetic isotope effects detailed mechanisms involving a hydroxy-λ4-sulfane intrmediate are proposed. The more reactive sulfonium salts with a five-membered hetero ring are hydrolyzed by water, whereas the sulfonium centre of the less reactive analogues with a six-membered ring is attacked only by OH- ions.
- Nagy, Peter,Csampai, Antal,Szabo, Denes,Varga, Jeno,Harmat, Veronika,Ruff, Ferenc,Kucsman, Arpad
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p. 339 - 349
(2007/10/03)
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- Antithrombotic agent
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Certain 2,2'-dithiobis-N-substituted or unsubstituted benzamides or derivatives thereof are useful as antithrombotic agents because of their ability to suppress aggregation of blood platelets.
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