253429-18-4

Basic information

• Product Name: 2-Bromo-1-(2,2-diethoxyethoxy)-4-fluorobenzene
• Synonyms: 2-Bromo-1-(2,2-diethoxyethoxy)-4-fluorobenzene
• CAS NO: 253429-18-4
• Molecular Formula: C₁₂H₁₆BrFO₃
• Molecular Weight: 307.1560432
• Mol File: 253429-18-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Bromo-1-(2,2-diethoxyethoxy)-4-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1-(2,2-diethoxyethoxy)-4-fluorobenzene(253429-18-4)
• EPA Substance Registry System: 2-Bromo-1-(2,2-diethoxyethoxy)-4-fluorobenzene(253429-18-4)

Safety Data

• Hazardous Substances Data: 253429-18-4(Hazardous Substances Data)

Upstream product

• 496-69-5 2-bromo-4-fluoro-phenol 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 325486-66-6 1-benzyl-3,3-dimethyl-4-hydroxy-4-(5-fluorobenzofuran-7-yl)-piperidine 
• 325486-56-4 1-benzyl-3-methyl-4-hydroxy-4-(5-fluorobenzofuran-7-yl)-piperidine 
• 325486-67-7 1-benzyl-3,3-dimethyl-4-(5-fluorobenzofuran-7-yl)-1,2,3,6-tetrahydropyridine 
• 325486-58-6 1-benzyl-3-methyl-4-(5-fluorobenzofur-7-yl)-1,2,5,6-tetrahydropyridine 
• 325486-57-5 1-benzyl-3-methyl-4-(5-fluorobenzofuran-7-yl)-1,2,3,6-tetrahydropyridine 
• 325488-23-1 1-benzyl-3-(5-fluorobenzofuran-7-yl)pyrrolidine 
• 325486-63-3 1-benzyl-3-methyl-4-(5-fluorobenzofuran-7-yl)piperidine 
• 1037759-77-5 6-(5-carbamoyl-2-fluorobenzyl)-4-fluoro-8-(2-oxo-1,2-dihydropyridin-3-yl)-6H-furo[2,3-e]indole-7-carboxylic acid 
• 253429-31-1 4-fluoro-7-bromo-benzo(b)furan 
• 555155-07-2 4-fluorobenzofuran-7-carbaldehyde 
• 555155-08-3 5-fluorobenzofuran-7-carboxaldehyde 
• 1379658-47-5 rac-1-(2-bromo-4-fluorophenoxy)-4-(2-phenoxyphenyl)but-3-yn-2-ol 
• 1082820-74-3 2-(2-bromo-4-fluorophenoxy)acetaldehyde 
• 253429-19-5 5-fluoro-7-bromo-benzo(b)furan 

Relevant articles and documents

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C–C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS

Novel tricyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.

NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OSTEOPOROSIS

Novel tricyclic compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.

Synthesis of tetrasubstituted alkenes through a palladium-catalyzed domino carbopalladation/C-H-activation reaction

Helical tetrasubstituted alkenes (7) were obtained in a highly efficient way through a palladium-catalyzed domino-carbopalladation/CH-activation reaction of propargylic alcohols 6 in good to excellent yields. Electron-withdrawing- and electron-donating substituents can be introduced onto the upper and lower aromatic rings. The substrates (6) for the domino process were synthesized by addition of the lithiated alkyne (20) to various aldehydes (19); moreover, the substrates were accessible enantioselectively (in 95 % ee) by reduction of the corresponding ketone using the Noyori procedure. Copyright

Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists

The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4′, R5, R5′, and R12 are as described in the specification.

SEROTONERGIC BENZOFURANS

The present invention provides serotonergic benzofurans of Formula (I): where A, R, R, R, R, and R are as described in the specification.

Pyrrolidine and pyrroline derivatives having effects on serotonin related systems

The present invention provides the compounds of the following formula (I): and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT1Areceptor and antagonizing the 5-HT2Areceptor which comprises administering to a subject in need of such treatment an effective amount of formula (I).

BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS

The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1, R2, R3, R4, R5, R5', R6, R6', R7, R7', R8, and R8' are as described in the specification.