General 5-Halomethyl Isoxazoline Synthesis Enabled by Copper-Catalyzed Oxyhalogenation of Alkenes
A general and efficient oxyhalogenation of unsaturated ketoximes has been achieved through copper catalysis with diethyl bromomalonate, N-chlorosuccinimide, and N-iodosuccinimide, yielding 5-chloromethyl, 5-bromomethyl, and 5-iodomethyl isoxazolines in go
Transition-metal-free oxychlorination of alkenyl oximes:: In situ generated radicals with tert -butyl nitrite
Oxychlorination of alkenyl oximes is harder compared to the analogous oxybromination or oxyiodination because of the difficulty associated with the formation of chlorine cations or radicals. A transition-metal-free oxychlorination of alkenyl oximes has be
Oxime-mediated oxychlorination and oxybromination of unactivated olefins
An oxime-mediated oxychlorination and oxybromination of unactivated olefins relying on palladium catalysis has been developed. A wide range of chlorinated and brominated isoxazolines has been synthesized in moderate to good yields. To demonstrate the value of the method, the brominated isoxazoline has been further converted to other useful synthetic feedstock.
Dong, Kui-Yong,Qin, Hai-Tao,Liu, Feng,Zhu, Chen
p. 1419 - 1422
(2015/03/04)
5-HT7 receptor antagonists
The present invention relates to compounds having pharmacological activity toward the 5-HT7receptor. Pharmaceutical compositions and methods for their use in the treatment of CNS disorders are described.
-
(2008/06/13)
More Articles about upstream products of 253443-43-5