253603-61-1

Basic information

• Product Name: 2-(PYRROLIDIN-3-YLOXY)-PYRIDINE
• Synonyms: 2-(PYRROLIDIN-3-YLOXY)-PYRIDINE;2-(3-PYRROLIDINYLOXY)-PYRIDINE
• CAS NO: 253603-61-1
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Mol File: 253603-61-1.mol

Chemical Properties

• Boiling Point: 262.1±30.0 °C(Predicted)
• Appearance: /
• Density: 1.113±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.17±0.10(Predicted)
• CAS DataBase Reference: 2-(PYRROLIDIN-3-YLOXY)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PYRROLIDIN-3-YLOXY)-PYRIDINE(253603-61-1)
• EPA Substance Registry System: 2-(PYRROLIDIN-3-YLOXY)-PYRIDINE(253603-61-1)

Safety Data

• Hazardous Substances Data: 253603-61-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(Pyrrolidin-3-yloxy)-pyridine is used as a precursor or intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-(Pyrrolidin-3-yloxy)-pyridine is utilized as a precursor or intermediate in the production of agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used as a Potential Insect Repellent:
2-(Pyrrolidin-3-yloxy)-pyridine has been studied for its potential as an insect repellent, offering a possible alternative to existing repellents for protecting against insect-borne diseases and nuisance.
Used in the Treatment of Medical Conditions:
2-(Pyrrolidin-3-yloxy)-pyridine has shown potential biological activities that may be beneficial in the treatment of various medical conditions. Its unique chemical structure allows for the exploration of its therapeutic potential in different areas of medicine.

Upstream product

• 109-09-1 2-chloropyridine 
• 372-48-5 2-fluoropyridine 
• 1224514-70-8 C₁₄H₂₀N₂O₃ 
• 253603-60-0 1-benzyl-3-(2-pyridyloxy)pyrrolidine 

Relevant articles and documents

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

A high-throughput screening (HTS) of the Genentech/Roche library identified a novel, uncharged scaffold as a KDM5A inhibitor. Lacking insight into the binding mode, initial attempts to improve inhibitor potency failed to improve potency, and synthesis of

2-(Aryloxy)ethylamine derivatives: Ring opened congeners of long chain 1-arylpiperazines with high 5-HT(1A) receptor affinity and selectivity versus D2 and α1 receptors

1-Aryl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1- yl)propyl]piperazine derivatives, previously reported as 5-HT(1A)/D2 ligands, were modified by opening the piperazine ring. Twenty-two ring opened congeners were prepared and their affinity for serotonin 5-HT(1A), dopamine D2, and α1-adrenergic receptors was measured in vitro. Among the herein reported compounds, the 2(aryloxy)ethylamine derivatives 38-40, 43 and 44 displayed 5-HT(1A) receptor affinity in the nanomolar range. In particular, compound 44 was found to be a potent and selective 5-HT(1A) ligand (K(i)= 0.71 nM), completely devoid of D2 and α1 receptor binding affinity. Our data indicate that removal of the ethylene chain of the piperazine ring, together with an isosteric substitution, can lead to ligand with high 5- HT(1A) receptor affinity and selectivity. Furthermore, compounds 40 and 44 were submitted to the [35S]GTPγS binding assay for a preliminary evaluation of their intrinsic activity on the 5-HT(1A) receptor.