- Chemical synthesis method of bosentan metabolite
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The invention discloses a chemical synthesis method of bosentan metabolite. According to the method disclosed by the invention, the bosentan metabolite is obtained from 2, 2-dimethyl methyl phenylacetate through six-step reaction. The whole preparation method is high in operability, high in preparation efficiency and low in production cost, and industrial mass production can be achieved. The bosentan metabolite prepared by the invention is higher in bioavailability, can directly play a role in resisting hypertension, and is lower in adverse reaction.
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Paragraph 0026; 0043-0045
(2021/07/08)
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