Process for manufacturing alkylphosphonate monoesters
The present invention discloses a process for manufacturing an alkylphosphonate monoester. The process may comprise partially hydrolyzing an alkyl phosphonate diester with an alkaline compound in a first solvent to provide a reaction mixture, wherein the first solvent comprises a mixture of an alcohol and water. The reaction mixture may be diluted with a second solvent to provide an organic phase, wherein the second solvent comprises at least one non-polar organic solvent. The process may comprise acidifying the reaction mixture with an acid, wherein the organic phase includes an alkylphosphonate monoester.
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Page 6
(2008/06/13)
Synthesis and structural study of long-chain hydrocarbon alkylphosphonic acids
Long-chain dialkyl alkylphosphonates were synthesized by radical addition of dialkyl hydrogenphosphonates onto alkenes in presence of di(t-butyl) peroxide. This synthetic route leads to high yields between 94 and 97%. We performed chemical modifications of these phosphonates in order to obtain acidic derivatives. The structure of these compounds was characterized by NMR analyses and mass spectroscopy. We also studied their thermal behaviour and various crystalline phases were put in evidence by differential scanning calorimetry and optical microscopy. The thermal stability of these compounds was compared by thermogravimetric analyses.
Gaboyard,Hervaud,Boutevin
p. 877 - 891
(2007/10/03)
PHOSPHONATE-CONTAINING ANALOGS OF CHOLESTERYL ESTER AS NOVEL INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN