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CAS

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25447-66-9

Dihydroergocryptine is a hydrogenated ergot alkaloid, specifically an equiproportional mixture of dihydroergocornine methanesulfonate, dihydroergocristine methanesulfonate, α and β-dihydroergocryptine methanesulfonate in the ratio of 1.5-2.5:1. It is an α-adrenergic blocker with a single bond replacing the double bond between positions 9 and 10, as defined by ChEBI.
Used in Pharmaceutical Industry:
Dihydroergocryptine is used as a pharmaceutical agent for the treatment of impaired mental function in the elderly. As an α-adrenergic blocker, it helps to improve cognitive function and overall mental health in elderly patients.

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  • 25447-66-9 Structure

  • Basic information

    1. Product Name: dihydroergocryptine
    2. Synonyms: dihydroergocryptine;9,10α-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'α-(2-methylpropyl)ergotaman-3',6',18-trione;9,10α-Dihydro-12'-hydroxy-2'-isopropyl-5'α-(2-methylpropyl)ergotaman-3',6',18-trion;9,10α-Dihydro-12'-hydroxy-2'-isopropyl-5'α-isobutylergotaman-3',6',18-trione;Dihydroergokryptine;(5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)ergotaMan-3',6',18-trione;9,10-Dihydroergocryptine;9,10-Dihydroergokryptine
    3. CAS NO:25447-66-9
    4. Molecular Formula: C32H43N5O5
    5. Molecular Weight: 577.71432
    6. EINECS: 246-993-6
    7. Product Categories: Aromatics, Heterocycles, Inhibitors, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 25447-66-9.mol

  • Chemical Properties

    1. Melting Point: 235 °C (decomp)
    2. Boiling Point: 848.7°C at 760 mmHg
    3. Flash Point: 467.1°C
    4. Appearance: /
    5. Density: 1.36g/cm3
    6. Vapor Pressure: 1.26E-30mmHg at 25°C
    7. Refractive Index: 1.667
    8. Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
    9. Solubility: DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
    10. PKA: pKa 6.89±0.07(H2O t=24 I≤0.01) (Uncertain)
    11. Stability: Hygroscopic
    12. CAS DataBase Reference: dihydroergocryptine(CAS DataBase Reference)
    13. NIST Chemistry Reference: dihydroergocryptine(25447-66-9)
    14. EPA Substance Registry System: dihydroergocryptine(25447-66-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 25447-66-9(Hazardous Substances Data)

25447-66-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 25447-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,4,4 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25447-66:
(7*2)+(6*5)+(5*4)+(4*4)+(3*7)+(2*6)+(1*6)=119
119 % 10 = 9
So 25447-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C32H43N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,15,17-18,20,22,24-26,33,41H,7,10-14,16H2,1-5H3,(H,34,38)/t20-,22-,24-,25+,26+,31-,32+/m1/s1

25447-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name dihydro-α-ergocryptine

1.2 Other means of identification

Product number -
Other names Dihydroergokryptine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25447-66-9 SDS

25447-66-9Upstream product

25447-66-9Relevant articles and documents

Synthesis of European pharmacopoeial impurities A, B, C, and D of cabergoline

Wagger, Jernej,Pozes, Aljaz,Pozgan, Franc

, p. 23146 - 23156 (2013/11/19)

For the use of analytics, European pharmacopoeial impurities A, B, C, and D of cabergoline were synthesized. Ergocryptine was chosen as a starting material and synthesis was accomplished via two approaches, different in length and stereochemical outcome. A longer, indirect approach was realized through otherwise problematic oxidations of the 9,10-dihidrolysergol derivative, to the corresponding aldehyde and carboxylic acid. This was achieved by the use of activated DMSO and a Pinnick oxidation sequence. All four synthesized impurities are used as analytical standards in cabergoline manufacturing processes.

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