DI- OR TRIPEPTIDE RENIN INHIBITORS CONTAINING LACTAM CONFORMATIONAL RESTRICTION IN ACHPA
Enzyme di-or tripeptides of the formula: STR1 and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.
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(2008/06/13)
Aziridino containing nitro imidazoles and pharmaceutical compositions
A compound of formula I STR1 in which formula: R1 represents hydrogen or an alkyl group; R2 -R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 1.
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(2008/06/13)
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