Mild and efficient deprotection of acetal-type protecting groups of hydroxyl functions by triethylsilyl triflate2,4,6-collidine combination
Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf2,4,6-collidine followed by H 20-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.