256373-26-9Relevant articles and documents
Structure activity relationships of fused bicyclic and urea derivatives of spirocyclic compounds as potent CCR1 antagonists
Hossain, Nafizal,Mensonides-Harsema, Marguérite,Cooper, Martin E.,Eriksson, Tomas,Ivanova, Svetlana,Bergstr?m, Lena
, p. 108 - 112 (2014/01/17)
A series of fused bicyclic and urea derivatives of spirocyclic compounds were designed, synthesised and evaluated in vitro as potent CCR1 antagonists. In particular, 4 (7 nM), 44 (1.3 nM), 48 (0.89 nM) and 50 (0.63 nM) were the most potent hCCR1 antagonis
NOVEL COMPOUNDS
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Page/Page column 33, (2010/02/12)
The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their prepa