- Efficient preparations of novel ynamides and allenamides
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Practical syntheses of a series of novel ynamides and allenamides are described here. While a base-induced isomerization protocol of propargyl amides leads to an array of chiral and achiral allenamides, ynamides are prepared from enamides via bromination followed by base-induced elimination of the Z-bromoenamides. These ynamides and allenamides possess improved thermal stability compared to ynamines and allenamines. They can be isolated, purified, and handled with ease, and thus, should be synthetically more useful than traditional ynamines and allenamines.
- Wei, Lin-Li,Mulder, Jason A.,Xiong, Hui,Zificsak, Craig A.,Douglas, Christopher J.,Hsung, Richard P.
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p. 459 - 466
(2007/10/03)
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- First stereoselective inverse demand [4 + 2] cycloaddition reactions of novel chiral allenamides with heterodienes. Preparation of highly functionalized 2-arylpyranyl heterocycles
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matrix presented The first stereoselective inverse demand [4 + 2] cycloaddition reactions of chiral allenamides with heterodienes are described here. These reactions lead to stereoselective synthesis of highly functionalized pyranyl heterocycles. A mechan
- Wei, Lin-Li,Hsung, Richard P.,Xiong, Hui,Mulder, Jason A.,Nkansah, Nancy T.
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p. 2145 - 2148
(2008/02/09)
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