- Structure activity relationship studies of some potent antifungal flavones, 4-thioflavones and 4-iminoflavones
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A series of flavones, carrying halogens, methoxy and nitro groups at various positions were synthesized by the Baker-Venkataraman rearrangement and were subsequently converted to 4-thioflavones and 4-iminoflavones. The synthesized compounds were evaluated for their in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. All synthesized compounds showed significant activity against T. longusus, A. flavus, M. canis and F. Solani but inactive against C. albicans and C. glabrata, respectively. 2-phenyl-4H-1-benzopyran-4-thiones were relatively more active than flavones and 4-iminoflavones. However, some compounds were even more active than standard miconazol and amphotericin B drugs.
- Hasan, Aurangzeb,Mughal,Sadiq
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scheme or table
p. 4361 - 4364
(2012/09/07)
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- Preparation of thioflavones via thiophosphoryl chloride mediated cyclodehydration and thionation of 1-(2-hydroxyphenyl)-3-arylpropane-1,3-diones
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A simple and convenient one-pot strategy for the preparation of thioflavones from 1,3-diketones is described. Cyclodehydration of a range of β-diketones and thionation of the resulting flavones was achieved using thiophosphoryl chloride (PSCl3) which serves as both a catalyst and thionating agent. Georg Thieme Verlag Stuttgart · New York.
- Vimal, Manorama,Pathak, Uma,Pandey, Lokesh Kumar,Suryanarayana, Malladi V. S.
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experimental part
p. 30 - 32
(2011/02/26)
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- Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones
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Synthesis of flavones, 4-thioflavones and 4-iminoflavones was carried out with the substitution of variable halogens, methyl, methoxy and nitro groups in the A, B and AB rings of the respective compounds and we also report here their antibacterial activity. Most of the synthesized compounds were found to be active against Escherichia coli, Bacillus subtilis, Shigella flexnari, Salmonella aureus, Salmonella typhi and Pseudomonas aeruginosa. Activity of 4-thioflavones and 4-iminoflavones was found to be higher than that of their corresponding flavone analogues. Investigated compounds having substituents like F, OMe and NO2 at 4′-position in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antibacterial activity.
- Ullah Mughal, Ehsan,Ayaz, Muhammad,Hussain, Zakir,Hasan, Aurangzeb,Sadiq, Amina,Riaz, Muhammad,Malik, Abdul,Hussain, Samreen,Choudhary, M. Iqbal
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p. 4704 - 4711
(2007/10/03)
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- A facile and cheap method for the conversion of flavones into 4-thioflavones using phosphorus pentasulfide and sodium hydrogen carbonate
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A facile, rapid, high yielding and relatively cheaper method has been developed for the synthesis of 4-thioflavones by using phosphorus pentasulfide and sodium hydrogen carbonate. Seven new and five known substituted 4-thioflavones prepared by this method are reported.
- Mughal, Ehsan Ullah,Hasan, Aurangzeb,Rasheed, Lubna
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p. 445 - 450
(2007/10/03)
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