- Efficient Synthesis of Bulky 2,2’-Bipyridine and (S)-Pyridine-Oxazoline Ligands
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Bulky N,N’-bidentate ligands can furnish catalysts with enhanced catalytic activity compared to commercially available ligands. Straightforward methods to effectively synthesize a broad range of these ligands, however, are uncommon. In this work, a simple and efficient method is developed for the synthesis of bulky N,N’-bidentate ligands, including 2,2’-bipyridines and enantioenriched pyridine-oxazolines. The Pd/NIXANTPHOS catalyst system enabled synthesis of a series of bulky 2,2’-bipyridine-based ligands and (S)-pyridine oxazoline-based enantioenriched ligands with good to excellent yields. The ligands have been benchmarked in the aminofluorination of styrene. (Figure presented.).
- Zheng, Zhipeng,Walsh, Patrick J.
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supporting information
p. 800 - 807
(2020/12/01)
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