Synthesis of α-amino and α-hydroxy acids under volcanic conditions: implications for the origin of life
Facile synthesis of α-hydroxy and α-amino acids is observed at temperatures from 145 to 280 °C with catalytic Ni2+, with cyano ligands as source for C and N, and with CO as a reductant and as a source for C. Implications for the problem of the origin of life are discussed.
Coupling of functional hydrogen bonds in pyridoxal-5′-phosphate- enzyme model systems observed by solid-state NMR spectroscopy
We present a novel series of hydrogen-bonded, polycrystalline 1:1 complexes of Schiff base models of the cofactor pyridoxal-5′-phosphate (PLP) with carboxylic acids that mimic the cofactor in a variety of enzyme active sites. These systems contain an intr
Sharif, Shasad,Schagen, David,Toney, Michael D.,Limbach, Hans-Heinrich
p. 4440 - 4455
(2008/02/02)
Stereoselective synthesis of stable isotope-labeled L-α-amino acids: Electrophilic amination of oppolzer's acyl sultams in the synthesis of L-[15N]alanine, L-[15N]valine, L-[15N]leucine, L-[15N]phenylalanine and
Using 1-chloro-1-[15N]nitrosocyclohexane, we have prepared five L-[α-15N]amino acids. The stereoselective electophillic hydroxyamination of (S)-acylbornane-10,2-sultams, followed by Zn(o)/H+ reduction, and alkaline cleavag
Lodwig,Unkefer
p. 239 - 248
(2007/10/03)
Chemo-Enzymatic Syntheses of Isotopically Labelled L-Amino Acids
L-Alanine labelled with carbon-13 and nitrogen-15 has been prepared in good yield and high optical purity from achiral precursors using alanine dehydrogenase.This versatile approach may be simply adapted for the preparation of a range of isotopically labe
Kelly, Nicholas M.,O'Neill, Bridget C.,Probert, John,Reid, Gordon,Stephen, Rosamund,et al.
p. 6533 - 6536
(2007/10/02)
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