- S1P1 AGONIST AND APPLICATION THEREOF
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The present invention relates to a class of tricyclic compounds and an application thereof as a sphingosine 1-phosphate type 1 (S1P1) receptor agonist. The invention specifically relates to a compound represented by formula (II), and a tautomer and pharmaceutically acceptable salt of same.
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Paragraph 0394-0397
(2021/10/02)
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- Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures
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We previously discovered m-carborane-containing estrogen receptor (ER) modulator 4, which exhibits weak ER-agonistic and antagonistic activities in transactivation assays. With the aim of developing novel ER partial agonists, we designed and synthesized v
- Ohta, Kiminori,Ogawa, Takumi,Kaise, Asako,Endo, Yasuyuki
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p. 3508 - 3514
(2014/06/23)
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- QUATERNARY AMMONIUM COMPOUND, PROCESS FOR PRODUCING THE SAME, THERAPEUTIC AGENT FOR CEREBROVASCULAR DISORDER, AND THERAPEUTIC AGENT FOR HEART DISEASE
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A quaternary ammonium compound of the present invention is a quaternary ammonium compound represented by general formula (I) or (I') (wherein, A represents a linear alkyl group having 1 to 4 carbon atoms, a branched alkyl group having 2 to 4 carbon atoms, a linear alkyl group having 1 to 4 carbon atoms and a hydroxyl group, or a branched alkyl group having 2 to 4 carbon atoms and a hydroxyl group, R 1 to R 3 may be the same or different and represent a linear or branched alkyl group having 1 to 12 carbon atoms, one of R 4 to R 8 represents CO 2 - or SO 3 - , while no more than three of the remaining R 4 to R 8 represent a group selected from the group consisting of a hydroxyl group and an alkoxy group having 1 to 4 carbon atoms, and other R 4 to R 8 represent a hydrogen atom, one of R' 4 to R' 8 represents CO 2 H or SO 3 H, no more than three of the remaining R' 4 to R' 8 represent a group selected from a protected hydroxyl group and an alkoxy group having 1 to 4 carbon atoms, while other R' 4 to R' 8 represent a hydrogen atom, and X - represents an anion capable of forming a salt with a quaternary ammonium group).
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Page/Page column 14-15
(2010/11/25)
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- POLYHETEROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
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The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X5, X6, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
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Page/Page column 38
(2010/02/13)
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