257874-86-5

Basic information

• Product Name: 2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-acetamide
• Synonyms: 2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-acetamide;2-(1-(3-(tert-butyldimethylsilyloxy)propyl)-1H-indol-3-yl)acetamide
• CAS NO: 257874-86-5
• Molecular Formula: C₁₉H₃₀N₂O₂Si
• Molecular Weight: 347
• Mol File: 257874-86-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-acetamide(257874-86-5)
• EPA Substance Registry System: 2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-acetamide(257874-86-5)

Safety Data

• Hazardous Substances Data: 257874-86-5(Hazardous Substances Data)

Usage

Molecular structure

2-1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl-acetamide has a complex structure that includes an indole ring and an acetamide group.

Silicon-containing functional group

The compound contains a tert-butyl-dimethyl-silanyloxy moiety, which is a silicon-containing functional group.

Properties and applications

The compound is likely to have properties and applications that are characteristic of both the indole and acetamide functional groups.

Reactivity

The presence of the silicon-containing moiety may contribute to the compound's reactivity.

Unique structure

The combination of functional groups in this compound makes it potentially interesting for various applications.

Organic synthesis

The compound may be useful in organic synthesis due to its unique structure and reactivity.

Pharmaceutical research

The compound may have potential applications in pharmaceutical research due to its combination of functional groups and reactivity.

Other applications in chemistry

The compound's unique structure and properties may make it suitable for various applications in the field of chemistry.

Upstream product

• 879-37-8 3-indolylacetamide 
• 89031-84-5 3-(tert-butyldimethylsilyloxy)propyl bromide 

Downstream Products

• 257878-84-5 3-[1-(3-hydroxypropyl)-1H-indol-3-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione 
• 257874-88-7 3-[1-(3-bromopropyl)-1H-indol-3-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione 
• 257878-86-7 3-[(3-chlorophenyl)amino]-4-[1-(3-hydroxypropyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione 
• 257874-87-6 3-{1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl}-4-phenylamino-pyrrole-2,5-dione 

Relevant articles and documents

Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

A series of novel 4-azaindolyl-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high potency to GSK-3β. Among them, compound 7c was the most promising GSK-3β inhibitor. Preliminary structure-activity relationships were discussed based on the experimental data obtained and showed that different substituents on the indole ring and side chains at 1-position of indole had varying degrees of influence on the GSK-3β inhibitory potency. In a cell-based functional assay, compounds 7c and 15a significantly reduced Aβ-induced Tau hyperphosphorylation by inhibiting GSK-3β.

Synthesis of anilino-monoindolylmaleimides as potent and selective PKCβ inhibitors

The synthesis and enzyme inhibitory activity of PKCIβ-selective inhibitors possessing the novel pharmacophore of anilino-monoindolylmaleimide are described.

KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula (I)

DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF

The present invention relates to a disubstituted maleimide compound of the formula [I] wherein R1 is hydrogen or alkyl, R2 is aryl, cycloalkyl or heterocyclic group, R3, R5, R6, R7 and Rsu