257937-23-8

Basic information

• Product Name: 3-broMo-4-(pyrrolidin-1-yl)pyridine
• Synonyms: 3-broMo-4-(pyrrolidin-1-yl)pyridine
• CAS NO: 257937-23-8
• Molecular Formula: C₉H₁₁BrN₂
• Molecular Weight: 227.10104
• Mol File: 257937-23-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-broMo-4-(pyrrolidin-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-broMo-4-(pyrrolidin-1-yl)pyridine(257937-23-8)
• EPA Substance Registry System: 3-broMo-4-(pyrrolidin-1-yl)pyridine(257937-23-8)

Safety Data

• Hazardous Substances Data: 257937-23-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
3-Bromo-4-(pyrrolidin-1-yl)pyridine is used as a building block for the synthesis of various chemical compounds and pharmaceutical drugs. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
As a reagent, 3-Bromo-4-(pyrrolidin-1-yl)pyridine is utilized in organic synthesis to create a range of chemical products, contributing to the advancement of chemical research and industry.
Used in Coordination Chemistry:
3-Bromo-4-(pyrrolidin-1-yl)pyridine also serves as a ligand in coordination chemistry, playing a crucial role in the formation and stabilization of metal complexes.
Used in Drug Development:
With its potential applications in the development of new drugs and materials, 3-Bromo-4-(pyrrolidin-1-yl)pyridine is an important component in the ongoing pursuit of innovative pharmaceutical solutions.
It is important to handle 3-Bromo-4-(pyrrolidin-1-yl)pyridine with care due to its potential health and environmental hazards if not properly managed.

Upstream product

• 2456-81-7 4-pyrrolidin-1-ylpyridine 

Relevant articles and documents

Single-Handed Helical Poly(quinoxaline-2,3-diyl)s Bearing Achiral 4-Aminopyrid-3-yl Pendants as Highly Enantioselective, Reusable Chiral Nucleophilic Organocatalysts in the Steglich Reaction

Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-aminopyrid-3-yl pendants were synthesized as new helical-polymer-based chiral nucleophilic organocatalysts. The obtained chiral nucleophilic polymer catalysts exhibited high catalytic activity, enantioselectivity, and reusability in asymmetric Steglich rearrangement of oxazolyl carbonate to C-carboxyazlactone. The polyquinoxaline-based, helically chiral DMAP catalyst mediated intramolecular acyl transfer selectively, by contrast with known small-molecule-based chiral organocatalysts, which also mediate intermolecular acyl transfers.

Configurationally Stable Biaryl Analogues of 4-(Dimethylamino)pyridine: A Novel Class of Chiral Nucleophilic Catalysts

A short synthetic approach toward a novel class of chiral nucleophilic catalysts, the dissymmetry of which stems from restricted rotation about an Ar-Ar bond, has been developed. The key steps of the synthesis include preparation of a nucleophilic 1-methyl-2-pyrrolino[3,2-c]pyridine core 16 by ortho-lithiation and creation of the biaryl axes via Suzuki cross-coupling reactions. Comparative HPLC studies of racemization for configurationally labile biaryls 31, 38, and 43 containing 1-methyl-2-pyrrolino[3,2-c]pyridine, 4-(dimethylamino)pyridine, and 4-(1-pyrrolidino)pyridine cores, respectively, have demonstrated that a pyrrolidino substituent ortho to the biaryl axis is optimal for slowing Ar-Ar rotation. Biaryls containing all three cores have been shown to retain DMAP-like catalytic activity in the acylation of a hindered alcohol. Biaryls 55 and 56, which are configurationally stable at ambient temperature, have also been prepared via modification of configurationally labile derivatives. Compounds 55 and 56 in optically pure form should provide a useful starting point for studies on catalytic asymmetric acyl transfer using atropisomeric analogues of DMAP.