- The synthesis of 5,7-dimethyl-1,2,4-triazolo[1,5a(14C)] pyrimidine-2-carbaldehyde from [14C]aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate
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Hydrazination of barium [14C]cyanamide and hydrazinolysis of S-methylisothio[14C]urea were compared for their ability to efficiently prepare [14C]aminoguanidine bicarbonate. [ 14C]Aminoguanidine bicarbonate was converted in three steps to 5, 7-dimethyl-1,2,4-triazolo[1,5a(14C)]pyrimidine-2-carbaldehyde, a key radiochemical GMP starting material. Copyright
- Rane, Anil M.,Klaas, Schildknegt
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scheme or table
p. 257 - 260
(2011/05/06)
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- PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
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The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.
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- Aminoguanidine bicarbonate with particular properties and method for making same
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The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine in the presence of CO2. The invention is characterised in that it consists in proceeding with an amount of cyamide slightly higher than the stoichiometric quantity. The invention also concerns quasi-spherical agglomerates of aminoguanidine bicarbonate crystals.
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Page/Page column 3
(2010/02/11)
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- 1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same
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1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): STR1 where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and A is (CH=CH)m (CH2)n OR, (CH=CH)m (CH2)n NR1 R2, (CH=CH)m (CH2)p B, OH, O(CH2)q OR, O(CH2)q NR1 R2 or O(CH2)r B; q is an integer from 2 to 5; r is an integer from 1 to 2; or the symbol - - - - represents a double bond, A is oxygen, CH(CH=CH)s (CH2)n OR, CH(CH=CH)s (CH2)n NR1 R2 or CH(CH=CH)s (CH2)p B; and L is ?CH=C(R3)!s CH=NR4 or ?CH=C(R3)!s CH2 NHR4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.
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- Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole
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A method for producing 3-amino-5-mercapto-1,2,4-triazole, useful as an intermediate compound for a medicine or pesticide, or the intermediate thereof, a salt of N-guanidino thiourea from aminoguanidine thiocyanate or a thiocyanate and an aminoguanidine compound in the presence of an acid in a polar solvent, or even from hydrazine and cyanamide is disclosed.
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