- Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors
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Novel triazoloquinazolines have been found as phosphodiesterase 10A (PDE10A) inhibitors. Structure-activity studies improved the initial micromolar potency which was found in the lead compound by a 100-fold identifying 5-(1H-benzoimidazol-2-ylmethylsulfan
- Kehler, Jan,Ritzen, Andreas,Langgard, Morten,Petersen, Sebastian Leth,Farah, Mohamed M.,Bundgaard, Christoffer,Christoffersen, Claus Tornby,Nielsen, Jacob,Kilburn, John Paul
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scheme or table
p. 3738 - 3742
(2011/07/31)
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- Domino cyclization of 2-isothiocyanatobenzonitrile with carboxylic hydrazides - One-pot synthesis of 1,2,4-triazolo[1,5-c]quinazoline-5(6H)-thiones
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One-pot reactions between carboxylic hydrazides and 2-isothiocyanatobenzonitrile afforded pharmacologically relevant 1,2,4-triazolo[1,5-c]quinazoline-5(6H)-thiones in good yields. These compounds were transformed into the corresponding amino-substituted derivatives in good yields in one of two steps. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
- Blank, Janet,Kandt, Madeleine,Pfeiffer, Wolf-Diethard,Hetzheim, Annemarie,Langer, Peter
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p. 182 - 189
(2007/10/03)
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- Synthesis and reactivity of 1,2,4-triazolo[1,5-c]quinazolines
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The preparation of 1,2,4-triazolo[1,5-c]quinazolines 4a-d, 5, 8a-d by cyclocondensation of 1a-c with carboxylic acids and carboxylic anhydrides, respectively, is described. By different pathways, the 5-thioxo-5,6-dihydro- 1,2,4-triazolo[1,5-c]quinazolines
- Pfeifer, Wolf-Diethard,Hetzheim, Annemarie,Pazdera, Pavel,Bodtke, Anja,Mücke, Jana
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p. 1327 - 1336
(2007/10/03)
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