- 1,1-Diphosphines and divinylphosphines via base catalyzed hydrophosphination
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A catalytic hydrophosphination route to 1,1-diphosphines is yet to be reported: these narrow bite angle pro-ligands have been used to great effect as ligands in homogeneous catalysis. We herein demonstrate that terminal alkynes readily undergo double hydrophosphination with HPPh2 and catalytic potassium hexamethyldisilazane (KHMDS) to generate 1,1-diphosphines. A change to H2PPh leads to the formation of P,P-divinyl phosphines.
- Coles,Mahon,Webster
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supporting information
p. 10443 - 10446
(2018/09/21)
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- Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones
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In the present study, a novel synthetic strategy to directly produce versatile 3-acylindoles through Rh(III)-catalyzed C-H activation and annulation cascade of N-phenylamidines with α-Cl ketones was developed, in which α-Cl ketones serve as unusual one-carbon (sp3) synthons. This strategy features high regioselectivity, efficiency, wide substrate tolerance, and mild reaction conditions, which further underscore its synthetic utility in drug molecule synthesis.
- Zhou, Jianhui,Li, Jian,Li, Yazhou,Wu, Chenglin,He, Guoxue,Yang, Qiaolan,Zhou, Yu,Liu, Hong
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supporting information
p. 7645 - 7649
(2018/12/11)
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- Facile N-arylation of amidines and N,N-disubstituted amidines
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A metal-free method for the N-arylation of amidines and N,N-disubstituted amidines using o-silylaryl triflate under very mild reaction conditions is developed. The reactions are compatible with a variety of functional groups. Imines can also be N-arylated by this method. Preparation of substituted phenanthridines via a Pd catalyzed intramolecular cyclization of the iodine containing N-arylation product is demonstrated.
- Yao, Tuanli
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supporting information
p. 4623 - 4626
(2015/07/08)
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- CuI-catalyzed amination of arylhalides with guanidines or amidines: A facile synthesis of 1-H-2-substituted benzimidazoles
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(Figure Presented) CuI/L5 (N,N′-dimethylethylenediamine) proves to be an efficient catalyst system for the amination of arylhalides with guanidines. The same catalyst system is then successfully applied to the one-step synthesis of 1-H-2-aminobenzimidazol
- Deng, Xiaohu,McAllister, Heather,Mani, Neelakandha S.
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supporting information; experimental part
p. 5742 - 5745
(2009/12/06)
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