- A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy
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A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed using the annulation of nitriles with hydrazines, which can be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas is liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles can be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provides a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals can be easily assembled in a one-pot manner. This journal is
- Zhang, Chunyan,Liang, Zuyu,Jia, Xiaofei,Wang, Maorong,Zhang, Guoying,Hu, Mao-Lin
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supporting information
p. 14215 - 14218
(2020/11/24)
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- Method for preparing 1,3,5-trisubstituted-1,2,4-triazole derivative in one step
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The invention discloses a method for preparing a 1,3,5-trisubstituted-1,2,4-triazole derivative in one step, and belongs to the technical field of organic chemical synthesis. According to the method,a simple nitrile compound and a hydrazine compound are u
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Paragraph 0026; 0096-0100; 0286-0290
(2020/08/12)
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- Multi-nitrogen compound and its synthetic method
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The invention relates to a multi-nitrogen compound and a synthesis method thereof. The synthesis method is a synthesis method of a multi-nitrogen heterocyclic compound employing copper acetate to participate into multi-component reaction of 2,3- allenoic
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Paragraph 0077; 0089-0091
(2017/02/24)
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- Substituent Effects in the Rearrangement of 4-Alkyl-4H-1,2,4-triazoles
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A study of the thermal rearrangement of neat 4-alkyl-substituted 4H-1,2,4-triazoles to the corresponding 1-alkyl-1H-1,2,4-triazoles showed that the rearrangement was accompanied by formation of 3,5-diphenyl-1H-1,2,4-triazole and alkenes.The composition of
- Gautun, Odd Reidar,Carlsen, Per H. J.
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p. 411 - 416
(2007/10/02)
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