Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis
Herein we report a highly efficient method for nickel-catalyzed C?N bond formation between sulfonamides and aryl electrophiles. This technology provides generic access to a broad range of N-aryl and N-heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy-transfer mechanism wherein C?N bond reductive elimination occurs from a triplet excited NiII complex. Late-stage sulfonamidation in the synthesis of a pharmacologically relevant structure is also demonstrated.
Kim, Taehoon,McCarver, Stefan J.,Lee, Chulbom,MacMillan, David W. C.
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p. 3488 - 3492
(2018/03/05)
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