- LIPOXYGENASE INHIBITORS
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Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.
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Paragraph 00545-00547
(2021/10/02)
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- A hydrochloric acid chlorine mi paming synthesis of intermediates method
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The invention discloses a synthetic method of a clomipramine hydrochloride intermediate, i.e. N-acetyl-3-chloroiminodibenzyl as shown in a structural formula (I), and the N-acetyl-3-chloroiminodibenzyl (I) is prepared by the step that N-acetyl iminodibenzyl as shown in a structural formula (II) as raw materials and chloride agents generate substitution reaction in a solvent in the presence of a catalyst and an acid-binding agent. Compared with the prior art, the synthetic method has the advantages of high yield, simple process, safety and reliability in operation, greenness and environmental friendliness and is suitable for industrial production, and economic and technical development of the bulk drug is promoted.
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Paragraph 0019; 0020
(2017/10/22)
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