260559-52-2

Basic information

• Product Name: (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, (4-chloro-2-formylphenyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl N-(4-chloro-2-formylphenyl)carbamate
• CAS NO: 260559-52-2
• Molecular Formula: C₁₂H₁₄ClNO₃
• Molecular Weight: 255.7
• Mol File: 260559-52-2.mol

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 315.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• PKA: 12.48±0.70(Predicted)
• CAS DataBase Reference: (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(260559-52-2)
• EPA Substance Registry System: (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(260559-52-2)

Safety Data

• Hazardous Substances Data: 260559-52-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a reagent in organic synthesis for its ability to protect amines, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a building block for the development of new pharmaceuticals, contributing to the creation of innovative treatments and therapies.
Used in Agrochemical Production:
(4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is utilized as a key component in the synthesis of agrochemicals, playing a role in the development of effective crop protection products and other agricultural applications.
Used in Chemical Research and Development:
Due to its stability and solubility-enhancing properties, (4-CHLORO-2-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is employed as a versatile tool in chemical research and development, aiding in the exploration of new chemical reactions and the optimization of existing processes.

Upstream product

• 106-47-8 4-chloro-aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 215249-94-8 (2'-amino-N'-tert-butoxycarbonyl-5'-chlorobenzylidene)-3-butenylamine 
• 215249-99-3 (2'-amino-N'-tert-butoxycarbonyl-5'-chlorobenzylidene)-trans-3-pentenylamine 

Relevant articles and documents

SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF

The present invention provides processes to manufacture substituted l-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b- tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.

Cyclizations of substituted benzylidene-3-alkenylamines: Synthesis of the tricyclic core of the martinellines

The martinellines (1 and 2) are natural products that possess both interesting biological activity and chemical structure. During the investigation of a hetero Diels-Alder route to these molecules, alternate Lewis acid-dependent cyclizations of (2'-amino-N'-tert-butoxycarbonyl-5'- chlorobenzylidene)-3-butenylamine (10) were observed. The reaction of a variety of imines with TMSOTf or TiCl4 led to the formation of different heterocycles including iminodibenzo[b,f][1,5]diazocines, hexahydropyrido[1,2- c]quinazolin-6-ones, tetrahydropyrrolo[1,2-c]quinazolin-5-ones, 2- arylpiperidines, and 2-arylpyrrolidines. Tetrahydropyrrolo[1,2-c]quinazolin- 5-one 54, obtained via this new methodology, was used as an intermediate in the synthesis of the tricyclic ring system (65) of the martinellines.