cas 2607-06-9, Diflucortolone | Articles data

Articles about 2607-06-9Total 3 be found

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Macrolactonolides: A novel class of anti-inflammatory compounds
A new concept in design of safe glucocorticoid therapy was introduced by conjugating potent glucocorticoid steroids with macrolides (macrolactonolides). These compounds were synthesized from various steroid 17β-carboxylic acids and 9a-N-(3-aminoalkyl) derivatives of 9-deokso-9a-aza-9a-homoeritromicin A and 3-descladinosyl-9-deokso-9a-aza-9a-homoeritromicin A using stable alkyl chain. Combining property of macrolides to preferentially accumulate in immune cells, especially in phagocyte cells, with anti-inflammatory activity of classic steroids, we designed molecules which showed good anti-inflammatory activity in ovalbumin (OVA) induced asthma in rats. The synthesis, in vitro and in vivo anti-inflammatory activity of this novel class of compounds are described.
Toma?kovi?, Linda,Komac, Marijana,Makaruha Stegi?, Oresta,Muni?, Vesna,Rali?, Jovica,Stani?, Barbara,Banjanac, Mihailo,Markovi?, Stribor,Hrva?i?, Bo?ka,?ip?i? Paljetak, Hana,Padovan, Jasna,Glojnari?, Ines,Erakovi? Haber, Vesna,Mesi?, Milan,Mer?ep, Mladen
p. 321 - 332
(2013/02/23)

PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS
The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone or Desoximetasone.
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(2012/02/05)

Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
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(2008/06/13)

Chemical Properties

Appearance/Colour :A white to pink crystalline
Melting Point: 220oC
Boiling Point: 534.005 °C at 760 mmHg
Flash Point:276.756 °C
Density: 1.295 g/cm³
Solubility:Chloroform (Slightly, Sonicated), DMSO (Slightly)
Storage Temp.:-20°C Freezer, Under inert atmosphere
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.562
PKA: 12.90±0.70(Predicted)
PSA: 74.60000
LogP: 2.72880

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2607-06-9

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Chemical Properties

Appearance/Colour :A white to pink crystalline

Melting Point: 220oC

Boiling Point: 534.005 °C at 760 mmHg

Flash Point:276.756 °C

Density: 1.295 g/cm³

Solubility:Chloroform (Slightly, Sonicated), DMSO (Slightly)

Storage Temp.:-20°C Freezer, Under inert atmosphere

Vapor Pressure: 0mmHg at 25°C

Refractive Index: 1.562

PKA: 12.90±0.70(Predicted)

PSA: 74.60000

LogP: 2.72880

Global suppliers and manufacturers of 2607-06-9total 33 suppliers on LookChem

Article Database

2607-06-9

Articles about 2607-06-9Total 3 be found

More Articles about upstream products of 2607-06-9

Chemical Properties

Appearance/Colour :A white to pink crystalline

Melting Point: 220oC

Boiling Point: 534.005 °C at 760 mmHg

Flash Point:276.756 °C

Density: 1.295 g/cm3

Solubility:Chloroform (Slightly, Sonicated), DMSO (Slightly)

Storage Temp.:-20°C Freezer, Under inert atmosphere

Vapor Pressure: 0mmHg at 25°C

Refractive Index: 1.562

PKA: 12.90±0.70(Predicted)

PSA: 74.60000

LogP: 2.72880

Global suppliers and manufacturers of 2607-06-9total 33 suppliers on LookChem

Density: 1.295 g/cm³