26172-54-3

Basic information

• Product Name: 2-Methyl-4-isothiazolin-3-one hydrochloride
• Synonyms: 3(2H)-Isothiazolone,2-methyl-,hydrochloride;MIT HYDROCHLORIDE;2-METHYL-4-ISOTHIAZOLIN-3-ONE HYDROCHLORIDE;2-methyl-2H-isothiazol-3-one hydrochloride;2-METHYL-4-ISOTHIAZOLIN-3-ONE HCL;N-MethylisothiazoloneHCl;ISO-THIAZOLINONE(KATHON);2-METHYLISOTHIAZOLONE (MIT) HCL, 99+%
• CAS NO: 26172-54-3
• Molecular Formula: C₄H₅NOS*ClH
• Molecular Weight: 151.61
• EINECS: 247-499-3
• Product Categories: Amines;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 26172-54-3.mol

Chemical Properties

• Boiling Point: 182.8 °C at 760 mmHg
• Flash Point: 64.3 °C
• Appearance: /
• Density: 1.551 at 21℃
• Vapor Pressure: 0.797mmHg at 25°C
• Storage Temp.: 2-8°C
• BRN: 3993054
• CAS DataBase Reference: 2-Methyl-4-isothiazolin-3-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-isothiazolin-3-one hydrochloride(26172-54-3)
• EPA Substance Registry System: 2-Methyl-4-isothiazolin-3-one hydrochloride(26172-54-3)

Safety Data

• Hazard Codes: C
• Statements: 34-42/43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 26172-54-3(Hazardous Substances Data)

Usage

Uses

Used in Personal Care Products:
2-Methyl-4-isothiazolin-3-one hydrochloride is used as a preservative in the personal care industry to prevent the growth of microorganisms in products like cosmetics, lotions, and shampoos. Its application helps maintain product quality and safety by inhibiting the development of harmful bacteria, fungi, and other microorganisms.
Used in Water Treatment:
In the water treatment industry, 2-Methyl-4-isothiazolin-3-one hydrochloride is used as a biocide to control microbial growth in water-containing solutions. This application is particularly important in industrial settings where water systems can become contaminated with harmful microorganisms, leading to potential health risks and equipment damage.
Used in Scientific Research:
2-Methyl-4-isothiazolin-3-one hydrochloride is also utilized in scientific research as a cytotoxic substance. It is employed to investigate its effects on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death. Additionally, it is used to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites, contributing to a better understanding of cellular processes and potential therapeutic applications.

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

InChI:InChI=1/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H

Upstream product

• 1002-19-3 3,3'-disulfanediylpropanamide 
• 7791-25-5 sulfuryl dichloride 

Relevant articles and documents

Process for preparing 4-isothiazolin-3-one

The present invention relates to an improved process for selectively preparing 4-isothiazolin-3-one having the following structural formula(I), consisted of preparing 3,3'-dithiodipropionyldichloride by reacting 3,3'-dithiodipropionic acid with thionylchloride, reacting with amine compound to prepare 3,3'-dithiodipropioneamide, and herein adding sulfrylchloride in organic solvent to cyclize, which is useful as antiseptic or anti-infectives for cooling water, metal processing oils, paints, cosmetics, surfactants, sensitizers, etc. STR1 wherein, R1 is methyl or n-octyl group; R2 is hydrogen or chlorine atom.