- Preparation method of 2-methyl-4-isothiazoline-3-one aqueous solution
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The invention provides a preparation method of a 2-methyl-4-isothiazoline-3-one aqueous solution. The method comprises the following concrete steps: uniformly mixing N,N'-dimethyl-3,3'-dithiodipropionamide or N-methyl-3-mercaptopropionamide with a solvent; adding a halogenating agent into the mixed solution, and carrying out a halogenation ring closing reaction; filtering to obtain a product, washing a filter cake with ethyl acetate, and drying to obtain a 2-methyl-4-isothiazoline-3-one hydrochloride solid; and dissolving the 2-methyl-4-isothiazoline-3-one hydrochloride solid by using a sodiumcarbonate aqueous solution to obtain an aqueous solution of which the pH value is 5.0-7.0 and the mass fraction of 2-methyl-4-isothiazoline-3-one is 50%. According to the invention, the purity of the2-methyl-4-isothiazoline-3-one obtained by the method reaches 99.9% or above, and the content of 5-chlorine-2-methyl-4-isothiazoline-3-one can be controlled to be 100 ppm or below.
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Paragraph 0031-0044; 0048-0050
(2020/12/31)
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- Preparation method of 3-isothiazolinone compound
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The invention discloses a preparation method of a 3-isothiazolinone compound, which comprises the following steps of adding raw materials and a solvent into a reaction system, and stirring and mixing,adding a dehydrating agent into the mixed solution, and stirring for reaction, introducing chlorine into the reaction system, stirring the reaction mixture for reaction, filtering and separating to obtain a product. According to the method, the chemical dehydrating agent is added into the reaction system to react with water or alcohol in the reaction system, so that water or alcohol in the systemis removed, side reaction caused by water or alcohol is avoided, the reaction yield is increased, and the economic benefit is remarkable.
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Paragraph 0033-0039
(2020/12/31)
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- Pipeline type continuous production method of 3-isothiazolinone compound
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The invention discloses a pipeline type continuous production method of a 3-isothiazolinone compound, which comprises the following steps: carrying out mixed reaction on a thioamide compound, a catalyst, a solvent and chlorine through a pipeline reactor system, and carrying out after-treatment after the reaction is completed to obtain the 3-isothiazolinone compound. According to the method, the defects of large occupied area, small productivity, low efficiency, high energy consumption and small safety coefficient caused by existing batch production of the 3-isothiazolinone compound are overcome; the invention provides a mode for continuously producing the 3-isothiazolinone compound, so that the reaction process is easy to control, energy consumption is reduced, the production efficiency and the safety coefficient of the production process are improved, and the process is an efficient and energy-saving safe production process.
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Paragraph 0018
(2019/12/02)
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- MICROBICIDE
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5-chloro-2-methyl-4-isothiazolin-3-yn as an active ingredient together with an, used in process for manufacturing a product of the co-organic solvent, in the residue and hydrolysates content of reduced for providing immunomodulated microbicidal, and ring alcoholic beverage group id amide 3-isothiazolone with a lactam-type including halogenation anger hydrogen salt neutralizing process device in manufacturing process, ring process moisture content as reaction solvent, the amount of acetic acid, ester and 0.1 weight % hereinafter, neutralizing step before the halogen anger hydrogen salt an ester of acetic acid dispersions obtained to filter out moisture content 0.1 weight % hereinafter in anger hydrogen salt halogen said hydrocarbon is added catalyst and a stabilizing agent to provide access to the filtration for solvent of exchanging and, moisture content collect the blood and to easily solvent exchange from process ring in addition 0.1 weight % hereinafter in an atmosphere of embodiment obtained with the device, which are in 5-chloro-2-methyl-4-isothiazoline-3-on as the active ingredient and, 10% weight concentration active ingredient when organic solvents and the Singer and total content of hydrolysate is microbicidal microbicides 200 888000000088 8 hereinafter.
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Paragraph 0065; 0067
(2016/12/07)
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- STABLE COMPOSITIONS OF THIABENDAZOLE AND IODINE-CONTAINING FUNGICIDES
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The present invention relates to stable compositions for the fungicidal equipment of thermoplastic polymers, in particular PVC, comprising thiabendazole, at least one iodine-containing fungicide and at least one epoxide and optionally further fungicidally active compounds, and also to methods for preparing these formulations and to uses thereof for the protection of thermoplastic polymers against attack and destruction by microorganisms. Moreover, the invention relates to mold-resistant PVC materials equipped with the compositions according to the invention.
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- FUNGICIDAL PENFLUFEN MIXTURES
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The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.
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- Isothiazoles. Part 14: New 3-aminosubstituted isothiazole dioxides and their mono- and dihalogeno derivatives
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3-Alkylamino- and 3-arylamino isothiazole dioxides unsubstituted at C-4 and C-5 were synthesized starting from dithiopropionic amides. Taking advantage of the direct chlorination during the cyclization process or realizing an addition-elimination process with bromine on the final 3-aminoisothiazole dioxide derivatives, the corresponding 5-chloro-, 4,5-dichloro- or the 4-bromoisothiazole dioxides could also be made available.
- Clerici, Francesca,Contini, Alessandro,Gelmi, Maria Luisa,Pocar, Donato
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p. 9399 - 9408
(2007/10/03)
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- Synergistic biocidal composition
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The invention relates to a biocidal composition which can be added to materials which can be attacked by harmful micro-organisms, containing pyrithione as a biocidal active ingredient. The biocidal composition is characterised in that it contains 2-alkyl isothiazoline-3-one as another biocidally active ingredient. The active ingredients of the biocidal composition behave synergistically and are ideally suitable for controlling bacteria, fungus and algae.
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- Bromonitrothienyldioxanes
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The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) in which R1, R2 and R3 are as defined in the description are highly suitable for use as biocides for protecting plants and industrial materials.
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- 3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS
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The 3-nitroisoxazoles of the formula (I) in which R1 and R2 are each as defined in the description, some of which are known, are highly suitable for use as biocides for protecting industrial materials.
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- Thiazines and thiazoles as agents for protecting materials
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The novel and known thiazines and thiazoles of the formula (I) in which R1, R2 and n are as defined in the description, are highly suitable for use as biocides for protecting industrial materials.
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- O-aryl dithiazole dioxides
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The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.
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- Method of preparing N,N′-disubstituted-3,3′-dithiodipropionamide and method of preparing substituted 3-isothiazolone by using the same
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A method of preparing N,N-disubstituted-3,3′-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropionamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and N-substituted-3-mercaptopropionamide reacts with an aqueous solution of hydrogen peroxide. In addition, a method of preparing substituted 3-isothiazolone is provided. In the method, the produced N,N-disubstituted-3,3′-dithiodipropionamide reacts with a halogenating agent, wherein X and Z are same or different and each selected from the group consisting of hydrogen or a lower alkyl group; Y is selected from the group consisting of hydrogen, an alkyl group of 1 to 18 carbon atoms, a cycloalkyl group of up to 10 carbon atoms, an aralkyl group of up to 10 carbon atoms, an aryl group of up to 10 carbon atoms, a halogen-, lower alkyl- or lower alkoxy-substituted aryl group, a cyano alkyl group, a carboalkoxyalkyl group, a haloalkyl group, an alkoxyalkyl group, an aryloxyalkyl group of up to 12 carbon atoms, an aralkoxyalkyl group of up to 12 carbon atoms, a dialkylaminoalkyl group, an alkylacyl group of up to 8 carbon atoms, a lower alkylsulfonyl group, an arylsulfonyl group of up to 10 carbon atoms, a cyano group and a carbamoyl group.
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- Agents for preserving technical materials against insects
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The use of the compounds of the formula (I) as agents for preserving technical materials against insects.
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- Wood preservatives
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Wood preservatives having biocidal properties which include quaternary ammonium compounds of general formula (I): wherein R1 is a C8-18-alkyl group or an optionally substituted benzyl group, R2 is a C8-18-alkyl group, R3 is a C1-4-alkyl group or a group of the formula —[CH2—CH2—O]n—H, R4 is a C1-4-alkyl group, n is a number from 0.5 to 8, preferably from 1 to 5, and A?is the anion of an organic carboxylic acid which contains 2 to 12 C atoms and carries at least one hydroxyl, amino or sulfonic acid group. The wood preservatives also penetrate deeply into the wood without the use of pressure, and have only a mild corrosive action on metals. Furthermore, a process for treating timbers with these compositions, concentrates for the preparation thereof, the use of new and known quaternary ammonium compounds in wood preservatives and new quaternary ammonium compounds and their use as biocides.
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- Dithiazoldioxides and the use thereof as microbicides
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The invention relates to novel dithiazole dioxides, to processes for their preparation and to their use in crop protection and in the protection of materials.
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- Arylthio-dithiazindioxides and their use as pesticides
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PCT No. PCT/EP97/07242 Sec. 371 Date Jun. 23, 1999 Sec. 102(e) Date Jun. 23, 1999 PCT Filed Dec. 22, 1997 PCT Pub. No. WO98/29400 PCT Pub. Date Jul. 9, 1998The invention relates to novel S-aryl-dithiazine dioxides, to processes for their preparation and to the use in crop protection and in the protection of materials.
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- Stabilized isothiazolone solution
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This invention relates to a stabilized isothiazolone solution and more particularly, to a stabilized isothiazolone solution comprising isothiazolone expressed by the following formula (I), stabilizer expressed by the following formula (II), and organic solvent diffusing these compounds effectively: STR1 In these formulae, n, R1, R2, R3, R4, and R5 have the same definitions as defined in the detailed description of this application, respectively.
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- N-sulfonyliminodithio compounds useful for in plant and material protection
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N-sulfonyliminodithio compounds have the formula (I), in which R1 and R2 stand for optionally substituted alkyl, alkenyl or alkinyl, and Ar stands for optionally substituted aryl; also disclosed are processes for preparing these compounds and their use for plant and material protection. STR1
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- 1,3,2-benzodithiazol-1-oxides as microbiocides
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A description is given of novel and know 1,3,2-benzodithiazole 1-oxides of the formula (I) STR1 and of their preparation and use for protecting industrial materials against infestation by microorganisms.
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- Mould-resistant emulsion paints
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The application relates to emulsion paints which are protected against fungal infestation by the use of N-alkyl-benzothiophene-2-carboxamide S,S-dioxides.
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- Thiazolylpyrazolinones and their use for protecting technical materials
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The present invention relates to novel thiazolylpyrazolinones, a process for their preparation and their use for the protection of technical materials.
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- Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock
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This application relates to new thiocarbamoyl compounds of the formula (I) STR1 in which R1, R2, R3 and R4 have the meanings given in the description.
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- Termite-controlling agent composition
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Combating termites with a composition comprising (a) at least one compound of the formula STR1 wherein, R denotes a hydrogen atom, acyl, alkyl or optionally substituted heteroarylalkyl, A denotes a hydrogen atom, alkyl or a bivalent group which binds to B, D denotes alkyl, --S--R1, STR2 or bivalent group or atom which binds to A. wherein R1 or R2 each independently denotes a hydrogen atom, acyl, alkyl or optionally substituted heteroarylalkyl. Y denotes =N-- or STR3 wherein T1 denotes a hydrogen atom or optionally substituted alkyl, and X denotes an electron attracting group, and (b) a pyrethoid compound.
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- Low-temperature-stabilized isothiazolinone concentrates
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A liquid concentrate comprises between about 4 and about 25 wt % of an isothiazolinone compound or mixture of isothiazolinone compounds between about 25 and about 88 wt % of a plasticizer in which said isothiazolinone compound is soluble and between about 8 and about 50 wt % of a C6 -C12 monoalkylphenol(s) which stabilizes the concentrate against crystallization and/or freezing at sub-freezing conditions.
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- Liquid isothiazolinone concentrates having improved low temperature-stability and improved anti-bacterial properties
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A liquid concentrate comprises between about 4 and about 10 wt % of an isothiazolinone compound or mixture of isothiazolinone compounds, between about 25 and about 92 wt % of a plasticizer in which said isothiazolinone compound is soluble and between about 4 and about 50 wt % of 2,4,4'-trichloro-2'-hydroxydiphenyl ether. The 2,4,4'-trichloro-2'-hydroxydiphenyl ether stabilizes the concentrate against crystallization and/or freezing at sub-freezing conditions, particularly when the isothiazolinone compound has a melting point of 30° C. or above. 2,4,4'-trichloro-2'-hydroxydiphenyl ether also enhances the anti-microbial properties of an isothiazolinone-containing concentrate.
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- Agents for preserving technical materials against insects
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Agents for preserving technical materials against insects, characterized in that they contain at least one compound of the formula (I) wherein Z represents 2-chloro-5-pyridiyl or 2-chloro-5-thiazolyl, and, R1 and R2 each independently represents hydrogen or C 1 4 alkyl.
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- Bromate as inhibitor of nitrosamine formation for nitrate stabilized isothiazolones and process
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An improved process for preparing a 3-isothiazolone of the formula STR1 wherein R and R1 are independently selected from hydrogen, halogen or R is a (C1 -C4) alkyl group and R1 is a halogen; Y is hydrogen, a (C1 -C18) alkyl group, an unsubstituted or halo-substituted (C2 -C8) alkenyl or alkynyl, a cycloalkyl or substituted (C3 -C12) cycloalkyl, an aralkyl or halo-, (C1 -C4) alkyl-, or (C1 -C4) alkoxy-substituted aralkyl of to 10 carbon atoms, or an aryl or halo-, (C1 -C4) alkyl-, or (C1 -C4) alkoxy-substituted aryl aryl group of up to 10 carbon atoms; comprising (a) reacting a disulfide ester with an amine to generate a disulfide amide; (b) contacting the disulfide amide with a halogenating agent in order to cyclize the amide to form the isothiazolone.HX; (c) neutralizing the isothiazolone.HX; (d) stabilizing the neutralized isothiazolone by adding a metal nitrate; (e) a heat treatment step the improvement comprising adding prior to step (e), after step (c) and before, during or after step (d), an amount of a metal bromate. Compositions resulting from the above process are disclosed.
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- 3-Isothiazolones as biocides
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Disclosed herein are certain novel compounds which are most properly designated as 3-isothiazolones. These compounds and compositions containing them exhibit a broad spectrum of biocidal properties and are particularly effective for the control of microorganisms.
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