262353-34-4Relevant articles and documents
Pyrimidine Derivatives with Terminal Pyridyl Heterocycles: Facile Synthesis and Their Antiproliferative Activities
Singh, Khushwant,Jana, Achintya,Lippmann, Petra,Ott, Ingo,Das, Neeladri
, p. 1866 - 1872 (2019)
Incorporation of heterocyclic pyrimidine or pyridine motifs is common in the drug design for various therapeutic applications. Herein, we describe the facile synthesis of two molecules containing both pyrimidine and pyridine scaffolds. A variety of analytical techniques (multinuclear NMR, Fourier transform infrared, and mass spectrometry analyses) confirmed the purity of these molecules. In pristine form, their potential as antitumor drugs was screened by investigating their cytotoxicity against various cell lines (cancerous and normal cells). Experimental results confirmed that the two molecules exhibited cell growth inhibition at very low concentrations. This was evident from their IC50 values that are in the range of 0.45–2.20 μM.
HETEROCYCLES CAPABLE OF MODULATING T-CELL RESPONSES, AND METHODS OF USING SAME
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Paragraph 00152; 00153, (2014/01/07)
The present disclosure is directed in part to heterocycles, and their use in treating medical disorders, such as immune inflammatory disorders such as Crohn's disease, ulcerative colitis, rheumatic disorders, psoriasis, and allergies. The compounds are co
Bis- and tris(arylethynyl)pyrimidine oligomers: synthesis and light-emitting properties
Achelle, Sylvain,Ramondenc, Yvan,Dupas, Georges,Plé, Nelly
, p. 2783 - 2791 (2008/09/19)
In this contribution, we describe the synthesis of bis- and tris(arylethylnyl)pyrimidine oligomers using Sonogashira, Negishi and Suzuki cross-coupling reactions and starting from chloro or iodopyrimidines. When the arms of such banana-shaped and star-sha
Arylation of halogenated pyrimidines via a suzuki coupling reaction
Schomaker,Delia
, p. 7125 - 7128 (2007/10/03)
The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.
First study of syntheses and reactivity of Grignard compounds in the diazine series. Diazines. Part 27
Leprêtre,Turck,Plé,Knochel,Quéguiner
, p. 265 - 273 (2007/10/03)
A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0°C or even room temperature.