262353-34-4

Basic information

• Product Name: 2,4-DIIODOPYRIMIDINE
• Synonyms: 2,4-DIIODOPYRIMIDINE
• CAS NO: 262353-34-4
• Molecular Formula: C₄H₂I₂N₂
• Molecular Weight: 331.874
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Halides;Pyrazines, Pyrimidines & Pyridazines;Heterocycle-Pyrimidine series
• Mol File: 262353-34-4.mol

Chemical Properties

• Melting Point: 125-126 °C
• Boiling Point: 365.115 °C at 760 mmHg
• Flash Point: 174.615 °C
• Appearance: /
• Density: 2.765 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.737
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -2.60±0.20(Predicted)
• CAS DataBase Reference: 2,4-DIIODOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIIODOPYRIMIDINE(262353-34-4)
• EPA Substance Registry System: 2,4-DIIODOPYRIMIDINE(262353-34-4)

Safety Data

• Hazardous Substances Data: 262353-34-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIIODOPYRIMIDINE is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique reactivity and potential for creating complex organic molecules contribute to the discovery and synthesis of novel drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DIIODOPYRIMIDINE serves as a key component in the synthesis of various agrochemicals. Its role in creating new chemical structures aids in the development of innovative products for crop protection and enhancement of agricultural yields.
Used in Academic Research:
2,4-DIIODOPYRIMIDINE is utilized as a research tool in academic settings to explore its chemical properties and reactivity. This helps in advancing the understanding of pyrimidine chemistry and contributes to the creation of new methodologies and synthetic pathways in organic chemistry.

InChI:InChI=1/C4H2I2N2/c5-3-1-2-7-4(6)8-3/h1-2H

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 

Downstream Products

• 262353-35-5 2-iodo-4-methoxypyrimidine 
• 25095-48-1 2,4-diphenylpyrimidine 
• 53618-63-6 2-iodo-4-phenylpyrimidine 
• 1018473-97-6 2,4-bis-phenylethynylpyrimidine 
• 1018473-98-7 2,4-bis-4-(N,N-dimethylamino)phenylethynylpyrimidine 
• 1450722-43-6 2,4-bis-[4-(2,6-diphenyl-pyran-4-ylidenemethyl)-phenylethynyl]-pyrimidine 

Relevant articles and documents

Pyrimidine Derivatives with Terminal Pyridyl Heterocycles: Facile Synthesis and Their Antiproliferative Activities

Incorporation of heterocyclic pyrimidine or pyridine motifs is common in the drug design for various therapeutic applications. Herein, we describe the facile synthesis of two molecules containing both pyrimidine and pyridine scaffolds. A variety of analytical techniques (multinuclear NMR, Fourier transform infrared, and mass spectrometry analyses) confirmed the purity of these molecules. In pristine form, their potential as antitumor drugs was screened by investigating their cytotoxicity against various cell lines (cancerous and normal cells). Experimental results confirmed that the two molecules exhibited cell growth inhibition at very low concentrations. This was evident from their IC50 values that are in the range of 0.45–2.20 μM.

HETEROCYCLES CAPABLE OF MODULATING T-CELL RESPONSES, AND METHODS OF USING SAME

The present disclosure is directed in part to heterocycles, and their use in treating medical disorders, such as immune inflammatory disorders such as Crohn's disease, ulcerative colitis, rheumatic disorders, psoriasis, and allergies. The compounds are co

Bis- and tris(arylethynyl)pyrimidine oligomers: synthesis and light-emitting properties

In this contribution, we describe the synthesis of bis- and tris(arylethylnyl)pyrimidine oligomers using Sonogashira, Negishi and Suzuki cross-coupling reactions and starting from chloro or iodopyrimidines. When the arms of such banana-shaped and star-sha

Arylation of halogenated pyrimidines via a suzuki coupling reaction

The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.

First study of syntheses and reactivity of Grignard compounds in the diazine series. Diazines. Part 27

A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0°C or even room temperature.