- Substituted 3-(2-Benzoxazyl)-benzimidazol-2-(1H)-ones: A new class of GABA(A) brain receptor ligands
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A novel class of potent benzodiazepine receptor (BZR) ligands has been designed and synthesized aided by molecular modeling of known benzodiazepine ligands such as CGS-8216 and the use of known pharmacophore models. (C) 2000 Elsevier Science Ltd.
- DeSimone, Robert W.,Blum, Charles A.
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p. 2723 - 2726
(2007/10/03)
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- SUBSTITUTED ARYL AND CYCLOALKYL IMIDAZOLONES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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Disclosed are compounds of the formula: STR1 wherein: T is NH, O, or S;X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide;the W ring is an optionally substituted aryl or heteroaryl group; and STR2 represents an optionally substituted benzo group or an optionally substituted 5, 6, 7, or 8 membered ring.These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
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- SYNTHESIS OF 4-IMIDAZOLIN-2-ONES
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The reaction of α-bromoketones with CO(NH2)2 and AcONH4 in aqueous acetic acid gave substituted 4-imidazolin-2-ones.
- Zav'yalov, S. I.,Sitkareva, I. V.,Ezhova, G. I.,Dorofeeva, O. V.,Zavozin, A. G.,Rumyantseva, E. E.
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p. 1297 - 1299
(2007/10/02)
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- About the Reaction between Hydrazines and Aminohydroxy-hydrobenzoxazol. Synthesis of Azoolefines
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By the reaction of 1-hydroxy-2-oxocyclohexane-carboxamide (1) with cyanamide 2-amino-7a-carbamoyl-3a-hydroxy-3a,4a,5,6,7,7a-hexahydrobenzoxazole (2) is formed.Compound 2 and arylhydrazine-hydrochloride yield 1-carbamoyl-2-arylazocyclohex-1-ene (4a, b).In
- Bischoff, Christian,Schroeder, Edith
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p. 177 - 183
(2007/10/02)
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