26286-55-5

Basic information

• Product Name: 2-(2-Methyl-1H-imidazol-1-yl)aniline
• Synonyms: 2-(2-Methyl-1H-imidazol-1-yl)aniline;2-(2-Methyl-1H-imidazol-1-yl)aniline 97%;2-(2-methyl-1-imidazolyl)aniline;2-(2-methylimidazol-1-yl)aniline;2-(2-Methyl-1H-imidazol-1-yl)aniline97%
• CAS NO: 26286-55-5
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21444
• Mol File: 26286-55-5.mol

Chemical Properties

• Melting Point: 132.5 °C
• Boiling Point: 372.167 °C at 760 mmHg
• Flash Point: 178.881 °C
• Appearance: /
• Density: 1.171 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.07±0.10(Predicted)
• CAS DataBase Reference: 2-(2-Methyl-1H-imidazol-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Methyl-1H-imidazol-1-yl)aniline(26286-55-5)
• EPA Substance Registry System: 2-(2-Methyl-1H-imidazol-1-yl)aniline(26286-55-5)

Safety Data

• Hazardous Substances Data: 26286-55-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-(2-Methyl-1H-imidazol-1-yl)aniline is utilized as a building block in organic synthesis for the development of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a key component in the creation of new and effective compounds.
Used in Dye Chemistry:
In the dye industry, 2-(2-Methyl-1H-imidazol-1-yl)aniline is employed as a precursor for the synthesis of dyes with specific color properties and stability. Its imidazolyl group contributes to the formation of dyes with desirable characteristics for various applications.
Used as a Corrosion Inhibitor in Metal Coatings:
2-(2-Methyl-1H-imidazol-1-yl)aniline is also studied for its potential as a corrosion inhibitor in metal coatings. Its ability to form protective layers on metal surfaces can enhance the durability and longevity of metal products, particularly in harsh environments.
Used in Biological and Pharmacological Research:
2-(2-Methyl-1H-imidazol-1-yl)aniline is investigated for its potential biological and pharmacological activities, such as antitumor and antimicrobial properties. Its unique chemical structure may offer new avenues for the development of therapeutic agents and treatments.

InChI:InChI=1/C10H11N3/c1-8-12-6-7-13(8)10-5-3-2-4-9(10)11/h2-7H,11H2,1H3

Upstream product

• 26286-51-1 2-methyl-1-(2-nitrophenyl)-1H-imidazole 
• 1493-27-2 ortho-nitrofluorobenzene 
• 693-98-1 2-methylimidazole 
• 615-43-0 2-iodophenylamine 
• 88-74-4 2-nitro-aniline 

Relevant articles and documents

Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and?Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors

The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the pharmaceutical industry seems to be

Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines.

In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives

Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-75

EFFICIENT LIGAND-MEDIATED ULLMANN COUPLING OF ANILINES AND AZOLES

The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.

Efficient ligand-mediated ullmann coupling of anilnies and azoles

The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.

Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues

A series of novel imidazoquinoxalinones and their aza analogues were prepared by the cyclization of o-amino(1H-imidazol-1-yl)aryls and heteroaryls with carbonyldiimidazole. The compounds were screened for inhibition of Type I and Type IV phosphodiesterase