263157-05-7

Basic information

• Product Name: 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL
• Synonyms: 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL;2,4-Dimethyl-5-(4-methyl-3-sulphanyl-4H-1,2,4-triazol-5-yl)-1,3-thiazole;5-(2,4-Dimethyl-1,3-thiazol-5-yl)-4-methyl-4H-1,2,4-triazole-3-thiol
• CAS NO: 263157-05-7
• Molecular Formula: C8H10N4S2
• Molecular Weight: 226.32
• Mol File: 263157-05-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL(263157-05-7)
• EPA Substance Registry System: 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL(263157-05-7)

Safety Data

• Hazardous Substances Data: 263157-05-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL is used as a pharmaceutical intermediate for the development of novel drugs and therapeutic agents. Its unique molecular structure and diverse pharmacological activities make it a valuable component in creating new treatments for various medical conditions.
Used in Cancer Treatment:
In the field of oncology, 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL is being studied for its potential in treating cancer. Its pharmacological properties are being investigated to understand its role in inhibiting tumor growth and progression, offering new avenues for cancer therapy.
Used in Infectious Disease Treatment:
5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL is also being explored for its potential in treating infectious diseases. Its antimicrobial properties are of interest to researchers and pharmaceutical companies looking to develop new treatments for bacterial and viral infections.
Used in Antioxidant Applications:
The antioxidant properties of 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL make it a candidate for use in applications that require protection against oxidative stress and damage. This can be particularly relevant in the development of pharmaceuticals aimed at preventing or treating conditions associated with oxidative stress.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 5-(2,4-DIMETHYLTHIAZOL-5-YL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL is being considered for use in applications that require effective agents against microorganisms. This can include the development of new antibiotics, antivirals, and antifungal agents to combat drug-resistant strains and emerging pathogens.

Upstream product

• 263157-04-6 C₈H₁₂N₄OS₂ 

Relevant articles and documents

Exploration of the amine terminus in a novel series of 1,2,4-Triazolo-3-yl- azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists

A novel series of 1,2,4-triazol-3-yl-azabicyclo[3.1.0]hexanes with high affinity and selectivity for the DA D3 receptor and excellent pharmacokinetic profiles was recently reported. We also recently discussed the role of the linker associated with the triazole moiety. In this manuscript, we are reporting a detailed exploration of the region of the receptor interacting with the amine terminus of the scaffold wherein SAR and developability data associated with these novel templates was undertaken.

1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: A new series of potent and selective dopamine D3 receptor antagonists

The discovery of new highly potent and selective dopamine (DA) D 3 receptor antagonists has recently allowed the characterization of the DA D3 receptor in a range of preclinical animal models of drug addiction. A novel series of 1,2,4-triazol-3-yl-azabicyclo[3.1.0]hexanes, members of which showed a high affinity and selectivity for the DA D3 receptor and excellent pharmacokinetic profiles, is reported here. Members of a group of derivatives from this series showed good oral bioavailability and brain penetration and very high in vitro affinity and selectivity for the DAD3 receptor, as well as high in vitro potency for antagonism at this receptor. Several members of this series also significantly attenuate the expression of conditioned place preference (CPP) to nicotine and cocaine. 2009 American Chemical Society.