263339-26-0

Basic information

• Product Name: Benzenamine, 4-(1-azetidinylmethyl)- (9CI)
• Synonyms: Benzenamine, 4-(1-azetidinylmethyl)- (9CI)
• CAS NO: 263339-26-0
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• Product Categories: AMINETERTIARY
• Mol File: 263339-26-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenamine, 4-(1-azetidinylmethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-(1-azetidinylmethyl)- (9CI)(263339-26-0)
• EPA Substance Registry System: Benzenamine, 4-(1-azetidinylmethyl)- (9CI)(263339-26-0)

Safety Data

• Hazardous Substances Data: 263339-26-0(Hazardous Substances Data)

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 263339-25-9 1-(4-nitrobenzyl)azetidine 

Relevant articles and documents

THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF

The present invention relates to compounds formula (I) and to salts thereof, wherein R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CDK8. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.

Substituted indolines which inhibit receptor tyrosine kinases

Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.