263349-73-1

Basic information

• Product Name: 4-Bromo-3-fluorobenzenesulfonamide
• Synonyms: 4-BROMO-3-FLUOROBENZENESULFONAMIDE;4-BROMO-3-FLUOROBENZENESULPHONAMIDE;BUTTPARK 80\03-34;4-Bromo-3-fluorobenzenesulphonamide 98%;4-Bromo-3-fluorobenzenesulphonamide98%;4-Bromo-3-fluorobenz;4-broMo-3-fluorobenzene-1-sulfonaMide;Benzenesulfonamide, 4-bromo-3-fluoro-
• CAS NO: 263349-73-1
• Molecular Formula: C₆H₅BrFNO₂S
• Molecular Weight: 254.08
• EINECS: -0
• Product Categories: Fluorobenzene;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Sulfur Compounds
• Mol File: 263349-73-1.mol

Chemical Properties

• Melting Point: 137-141 °C(lit.)
• Boiling Point: 360.1 °C at 760mmHg
• Flash Point: 171.6 °C
• Appearance: /
• Density: 1.83 g/cm³
• Vapor Pressure: 0.0762mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.68±0.60(Predicted)
• CAS DataBase Reference: 4-Bromo-3-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-fluorobenzenesulfonamide(263349-73-1)
• EPA Substance Registry System: 4-Bromo-3-fluorobenzenesulfonamide(263349-73-1)

Safety Data

• Hazard Codes: Xi
• Statements: 22-36/37/38
• Safety Statements: 22-36/37-37-26
• WGK Germany: 3
• PackingGroup: I
• Hazardous Substances Data: 263349-73-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
4-Bromo-3-fluorobenzenesulfonamide is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a versatile component in the creation of new compounds with potential therapeutic or pesticidal properties.
Used in Medicinal Chemistry and Drug Development:
In the field of medicinal chemistry, 4-Bromo-3-fluorobenzenesulfonamide is utilized as a key component in the development of new drugs. Its ability to interact with biomolecules and enzymes makes it a valuable asset in designing drugs that can target specific biological pathways or receptors.
Used in Industrial Production of Dyes:
4-Bromo-3-fluorobenzenesulfonamide may also find use in the industrial production of dyes, where its chemical structure could contribute to the color and stability of the dyes produced.
Used in Organic Synthesis Processes:
4-Bromo-3-fluorobenzenesulfonamide is employed in various organic synthesis processes, where its reactivity and structural features can be leveraged to produce a range of organic compounds for different applications.

InChI:InChI=1/C10H11FO/c1-7(2)10(12)8-3-5-9(11)6-4-8/h3-7H,1-2H3

Upstream product

• 351003-51-5 4-bromo-3-fluorobenzene-1-sulfonyl chloride 

Downstream Products

• 896718-71-1 4-ethynyl-3-fluorobenzenesulfonamide 
• 1454649-62-7 4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide 

Relevant articles and documents

Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration

Currently, the therapeutic options for treatment of liver failure are very limited. As mitogen-activated protein kinase kinase 4 (MKK4) has recently been identified by in vivo RNAi experiments to be a major regulator in hepatocyte regeneration, we pursued the development of a small molecule targeting this protein kinase. Starting from the approved BRAFV600E inhibitor vemurafenib (8), that showed a high off-target affinity to MKK4 in an initial screening, we followed a scaffold-hopping approach, changing the core heterocycle from 1H-pyrrolo[2,3-b]pyridine to 1H-pyrazolo[2,3-b]pyridine (10). Affinity to MKK4 could be conserved while the selectivity against off-target protein kinases was slightly improved. Further modifications led to 58 and 59 showing high affinity to MKK4 in the low nanomolar range and excellent selectivity profile from mandatory multiparameter-optimization for the essential anti-targets (MKK7, JNK1) and off-targets (BRAF, MAP4K5, ZAK) in the MKK4 pathway. Herein we report the first selective MKK4 inhibitors in this class.

PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

ARYL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR

In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; trea