The present disclosure describes novel heterocyclic PRMT5 inhibitors and methods for preparing them. The pharmaceutical compositions comprising such PRMT5 inhibitors and methods of using them for treating cancer, infectious diseases, and other PRMT5 associated disorders are also described.
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Paragraph 082; 157; 214
(2020/12/11)
Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: Generality, scope, and mechanism of the reaction
The scope, generality, and mechanism of the Dess-Martin periodinane-mediated cyclization reaction of unsaturated anilides discovered during the total synthesis of the CP-molecules (phomoidrides A and B) are delineated. A plethora of heterocyclic compounds
Nicolaou,Baran,Zhong,Sugita
p. 2212 - 2220
(2007/10/03)
New synthetic technology for the rapid construction of novel heterocycles - Part 1: The reaction of Dess - Martin periodinane with anilides and related compounds
The unusual behavior of hypervalent iodine reagents, Dess - Martin periodinane and IBX, with an array of anilides leads to the formation of complex heterocycles in only one synthetic operation. Furthermore, the substrates for these transformations are ava
Nicolaou,Zhong, Yong-Li,Baran, Phil S.
p. 622 - 625
(2007/10/03)
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