263711-74-6

Basic information

• Product Name: Apigenin-D5
• Synonyms: Apigenin-D5;[3,6,8,35d5]-Apigenin;4',5,7-Trihydroxyflavone-d5;5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5;Pelargidenon 1449-d5;Apigenin-d5 (Major)
• CAS NO: 263711-74-6
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 275.2677
• Product Categories: Inhibitors;Isotope Labeled Compounds;Isotope Labelled Compounds
• Mol File: 263711-74-6.mol

Chemical Properties

• Melting Point: 345-350°C
• Boiling Point: 555.505 °C at 760 mmHg
• Flash Point: 217.064 °C
• Appearance: Pale Yellow Crystalline Solid
• Density: 1.577 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: Apigenin-D5(CAS DataBase Reference)
• NIST Chemistry Reference: Apigenin-D5(263711-74-6)
• EPA Substance Registry System: Apigenin-D5(263711-74-6)

Safety Data

• Hazardous Substances Data: 263711-74-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
Apigenin-D5 is used as an internal standard for the quantification of apigenin in pharmaceutical research. This application is crucial for ensuring accurate and reliable measurements of apigenin levels in various samples, such as biological tissues, fluids, and pharmaceutical formulations.
Used in Research and Development:
Apigenin-D5 is used as a research tool in the study of CK2 inhibition and its potential therapeutic applications. By inhibiting CK2 activity, apigenin has demonstrated the ability to improve renal function in a rat model of glomerulonephritis, decrease the degradation of IκBα, down-regulate NF-κB levels in WEHI-231 cells, and inhibit the synthesis of inflammatory mediators nitric oxide and prostaglandin E2.
Used in Analytical Chemistry:
Apigenin-D5 is employed as a reference compound in the development and validation of analytical methods for the determination of apigenin in complex matrices. Its use as an internal standard helps to correct for any variations in sample preparation, instrumental response, and other factors that may affect the accuracy of the measurements.
Used in Quality Control:
Apigenin-D5 is utilized in the quality control of pharmaceutical products containing apigenin or its derivatives. By comparing the response of the sample to that of the internal standard, it is possible to ensure the consistency, purity, and potency of the active ingredient in the final product.

InChI:InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H/i3D,4D,5D,6D,7D

Upstream product

• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 263711-81-5 C₁₅H₇⁽²⁾H₃O₅ 

Relevant articles and documents

Synthesis of deuterium labeled polyhydroxy flavones and 3-flavonols

Syntheses are described for seven new deuterium labeled flavones, [3,6,8,3',5'-D5]-apigenin 5, [3,3',5'-D3]-apigenin 6, [3,6,8,2',5',6'-D6]- luteolin 7, [3,2',5',6'-D4]-luteolin 8, [6,8,2',5',6'-D5]-q

Expedient deuterolabeling of polyphenols in ionic liquids - DCl/D 2O under microwave irradiation

(Chemical Equation Presented) Postsynthetic regioselective aromatic ring H/D exchanges in polyphenolic compounds are rapidly performed in high yields and isotopic purities in ionic liquid-DCl/D2O under microwave irradiation. Other C-H bonds, in