Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors
Starting with the published 2.0 A X-ray crystal structure of the transthyretin.(flufenamic acid)2 complex, a simple structure-based ligand design strategy was employed to conceive of N-phenyl phenoxazine transthyretin (TTR) amyloid fibril inhib
Petrassi, H. Michael,Klabunde, Thomas,Sacchettini, James,Kelly, Jeffery W.
p. 2178 - 2192
(2007/10/03)
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