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AMINO((1-AZA-2-(3-(TRIFLUOROMETHYL)PHENYL)VINYL)AMINO)METHANE-1-THIONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 264148-89-2 Structure
  • Basic information

    1. Product Name: AMINO((1-AZA-2-(3-(TRIFLUOROMETHYL)PHENYL)VINYL)AMINO)METHANE-1-THIONE
    2. Synonyms: AMINO((1-AZA-2-(3-(TRIFLUOROMETHYL)PHENYL)VINYL)AMINO)METHANE-1-THIONE
    3. CAS NO:264148-89-2
    4. Molecular Formula: C9H8F3N3S
    5. Molecular Weight: 247.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 264148-89-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: AMINO((1-AZA-2-(3-(TRIFLUOROMETHYL)PHENYL)VINYL)AMINO)METHANE-1-THIONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: AMINO((1-AZA-2-(3-(TRIFLUOROMETHYL)PHENYL)VINYL)AMINO)METHANE-1-THIONE(264148-89-2)
    11. EPA Substance Registry System: AMINO((1-AZA-2-(3-(TRIFLUOROMETHYL)PHENYL)VINYL)AMINO)METHANE-1-THIONE(264148-89-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 264148-89-2(Hazardous Substances Data)

264148-89-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 264148-89-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,4,1,4 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 264148-89:
(8*2)+(7*6)+(6*4)+(5*1)+(4*4)+(3*8)+(2*8)+(1*9)=152
152 % 10 = 2
So 264148-89-2 is a valid CAS Registry Number.

264148-89-2Downstream Products

264148-89-2Relevant articles and documents

Assessment of Thiosemicarbazone-Containing Compounds as Potential Antileukemia Agents against P-gp Overexpressing Drug Resistant K562/A02 Cells

Gu, Xiaoke,Guan, Mingyu,Jiang, Chunyu,Song, Qinghua,Li, Xin,Sun, Nan,Chen, Jing,Qiu, Jingying

, (2021/01/15)

P-Glycoprotein (P-gp) overexpression is considered to be the leading cause of multidrug resistance (MDR) and failure of chemotherapy for leukemia. In this study, seventeen thiosemicarbazone-containing compounds were prepared and evaluated as potential ant

Synthesis of 2-amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via sequential condensation and I2-mediated oxidative C-O/C-S bond formation

Niu, Pengfei,Kang, Jinfeng,Tian, Xianhai,Song, Lina,Liu, Hongxu,Wu, Jie,Yu, Wenquan,Chang, Junbiao

, p. 1018 - 1024 (2015/01/30)

2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C-O/C-S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.

Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use

-

Page/Page column 14, (2008/06/13)

The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also fin

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain

Du, Xiaohui,Guo, Chun,Hansell, Elizabeth,Doyle, Patricia S.,Caffrey, Conor R.,Holler, Tod P.,McKerrow, James H.,Cohen, Fred E.

, p. 2695 - 2707 (2007/10/03)

American trypanosomiasis, or Chagas' disease, is the leading cause of heart disease in Latin America. Currently there is an urgent need to develop antitrypanosomal therapy due to the toxicity of existing agents and emerging drug resistance. A novel series of potent thio semicarbazone small-molecule inhibitors of the Trypanosoma cruzi cysteine protease cruzain have been identified. Some of these inhibitors have been shown to be trypanocidal. We initially discovered that 3′-bromopropiophenone thio semicarbazone (1i) inhibited cruzain and could cure mammalian cell cultures infected with T. cruzi. 3′-Bromopropiophenone thio semicarbazone showed no toxicity for mammalian cells at concentrations that were trypanocidal. Following this lead, more than 100 compounds were designed and synthesized. A specific structure-activity relationship (SAR) was established, and many potent analogues with IC50 values in the low nanomolar range were identified. Eight additional analogues were trypanocidal in a cell culture assay, and this indicates that aryl thio semicarbazone is a productive scaffold for killing the parasites. Kinetic studies show that these are time-dependent inhibitors. Molecular modeling studies of the enzyme-inhibitor complex have led to a proposed mechanism of interaction as well as insight into the SAR of the thio semicarbazone series. The nonpeptide nature of this series, small size, and extremely low cost of production suggest this is a promising direction for the development of new antitrypanosome chemotherapy.

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