- Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp.
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Two new compounds, the peptide-polyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from a Streptomyces sp. cultivated from the gastropod mollusk Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine. The application of Marfey's method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR.
- Lin, Zhenjian,Flores, Malem,Forteza, Imelda,Henriksen, Niel M.,Concepcion, Gisela P.,Rosenberg, Gary,Haygood, Margo G.,Olivera, Baldomero M.,Light, Alan R.,Cheatham, Thomas E.,Schmidt, Eric W.
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experimental part
p. 644 - 649
(2012/06/29)
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