Allenylphosphine oxides as simple scaffolds for phosphinoylindoles and phosphinoylisocoumarins
A range of phosphinoylindoles was prepared in one-pot from functionalized propargyl alcohols and a suitable P(III) precursor via a base-mediated reaction. The reaction proceeds via the intermediacy of allenylphosphine oxides. Similarly, phosphinoylisocoumarins were prepared from allenylphosphine oxides in a trifluoroacetic acid-mediated reaction; the latter also acts as a solvent. Interestingly, in the presence of wet trifluoroacetic acid, in addition to phosphinoylisocoumarins, phosphorus-free isocoumarins were also obtained. Key products were characterized by single crystal X-ray crystallography.
Gangadhararao,Kotikalapudi, Ramesh,Reddy, M. Nagarjuna,Swamy Kumara
supporting information
p. 996 - 1005
(2014/05/20)
3-SUBSTITUTED ISOCOUMARINS FROM PHTHALIDE-3-PHOSPHONATES. A NOVEL SYNTHESIS
The title transformation was carried out in two steps by C(3) acylation of the phosphonate reagent followed by reduction with zinc in acetic acid.
Napolitano, Elio,Ramacciotti, Antonella
p. 443 - 444
(2007/10/02)
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