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26585-13-7

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Synthesis and evaluation of β-carbolinium cations as new antimalarial agents based on π-delocalized lipophilic cation (DLC) hypothesis
Several β-carbolines including naturally occurring substances and their corresponding cationic derivatives were synthesized and evaluated for antimalarial (antiplasmodial) activity in vitro and in vivo. A tetracyclic carbolinium salt was elucidated for antileishmanial and antitrypanosomal activities in vitro as well as antiplasmodial activity. Quarternary carbolinium cations showed much higher potencies in vitro than electronically neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic (DLC) structure and antimalarial efficacy. β-Carbolinium compounds exhibit medium suppressive activity in vivo against rodent malaria.
Takasu, Kiyosei,Shimogama, Tsubasa,Saiin, Chalerm,Kim, Hye-Sook,Wataya, Yusuke,Brun, Reto,Ihara, Masataka
p. 653 - 661
(2007/10/03)

π-Delocalized β-carbolinium cations as potential antimalarials
Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines
Takasu, Kiyosei,Shimogama, Tsubasa,Saiin, Chalerm,Kim, Hye-Sook,Wataya, Yusuke,Ihara, Masataka
p. 1689 - 1692
(2007/10/03)

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26585-14-8
crenatine

Chemical Properties

Boiling Point: 461.2 °C at 760 mmHg
Flash Point:151.1 °C
Density: 1.251 g/cm³
Vapor Pressure: 3E-08mmHg at 25°C
Refractive Index: 1.737
PSA: 37.91000
LogP: 3.36770

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